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Alox5ap Gene Detail
Summary
  • Symbol
    Alox5ap
  • Name
    arachidonate 5-lipoxygenase activating protein
  • Synonyms
    arachidonate 5 lipoxygenase activating protein, Flap
  • Feature Type
    protein coding gene
  • IDs
    MGI:107505
    NCBI Gene: 11690
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:149201814-149224963 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 89.18 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    737 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107505
 protein coding gene Chr5:149201577-149224963 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030401
 protein coding gene Chr5:155080294-155108937 (+)
A/J MGP_AJ_G0030374
 protein coding gene Chr5:148475849-148499136 (+)
AKR/J MGP_AKRJ_G0030301
 protein coding gene Chr5:153058884-153083362 (+)
BALB/cJ MGP_BALBcJ_G0030383
 protein coding gene Chr5:149720636-149745641 (+)
C3H/HeJ MGP_C3HHeJ_G0030097
 protein coding gene Chr5:154045566-154069140 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030838
 protein coding gene Chr5:160783083-160811802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028051
 protein coding gene Chr5:142823318-142847120 (+)
CAST/EiJ MGP_CASTEiJ_G0029499
 protein coding gene Chr5:153649622-153685878 (+)
CBA/J MGP_CBAJ_G0030075
 protein coding gene Chr5:167522098-167552191 (+)
DBA/2J MGP_DBA2J_G0030219
 protein coding gene Chr5:148128130-148151953 (+)
FVB/NJ MGP_FVBNJ_G0030173
 protein coding gene Chr5:147374420-147404635 (+)
LP/J MGP_LPJ_G0030306
 protein coding gene Chr5:155771376-155802863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030209
 protein coding gene Chr5:169664309-169689188 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030868
 protein coding gene Chr5:152978708-153008303 (+)
PWK/PhJ MGP_PWKPhJ_G0029213
 protein coding gene Chr5:147282639-147308831 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029049
 protein coding gene Chr5:150284183-150311608 (+)
WSB/EiJ MGP_WSBEiJ_G0029576
 protein coding gene Chr5:153795856-153821006 (+)



Homology
more
  • Human Ortholog
    ALOX5AP, arachidonate 5-lipoxygenase activating protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALOX5AP, arachidonate 5-lipoxygenase activating protein
  • Synonyms
    FLAP
  • Links
    NCBI Gene ID: 241
    neXtProt AC: NX_P20292
    UniProt: P20292

  • Chr Location
    13q12.3; chr13:30713478-30764426 (+)  GRCh38
Human Diseases
more
  • Diseases
    8 with human ALOX5AP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutations of this gene result in a complete defect in leukotriene production, resistance to platelet-activating factor mediated anaphylaxis, and reduced acute and chronic inflammatory responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    53
  • cDNA Data
    22
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11690 NCBI Gene Model | MGI Sequence Detail 23150 C57BL/6J ±  kb
    transcript NM_009663 RefSeq | MGI Sequence Detail 1031 C57BL/6  
    polypeptide P30355 UniProt | EBI | MGI Sequence Detail 161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003962 arachidonate 5-lipoxygenase-activating protein
      (term hierarchy)
    • InterPro Domains
      IPR001446 5-lipoxygenase-activating protein
      IPR018295 FLAP/GST2/LTC4S, conserved site
      IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
      IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
      IPR050997 Membrane-associated proteins in eicosanoid and glutathione metabolism
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 24
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36075
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:46832 Vickers PJ, et al., Cross-species comparison of 5-lipoxygenase-activating protein. Mol Pharmacol. 1992 Dec;42(6):1014-9
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory