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Gata6 Gene Detail
Summary
  • Symbol
    Gata6
  • Name
    GATA binding protein 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:107516
    NCBI Gene: 14465
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:11052510-11085636 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 5.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    833 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107516
 protein coding gene Chr18:11052064-11085636 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024152
 protein coding gene Chr18:8011019-8055645 (+)
A/J MGP_AJ_G0024114
 protein coding gene Chr18:7934270-7967702 (+)
AKR/J MGP_AKRJ_G0024081
 protein coding gene Chr18:8154826-8188215 (+)
BALB/cJ MGP_BALBcJ_G0024113
 protein coding gene Chr18:7922873-7958414 (+)
C3H/HeJ MGP_C3HHeJ_G0023880
 protein coding gene Chr18:8048651-8085073 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024558
 protein coding gene Chr18:8478120-8516202 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021997
 protein coding gene Chr18:7617046-7649933 (+)
CAST/EiJ MGP_CASTEiJ_G0023357
 protein coding gene Chr18:7959283-8017708 (+)
CBA/J MGP_CBAJ_G0023852
 protein coding gene Chr18:8553278-8593634 (+)
DBA/2J MGP_DBA2J_G0023981
 protein coding gene Chr18:7807672-7841661 (+)
FVB/NJ MGP_FVBNJ_G0023946
 protein coding gene Chr18:7761825-7795019 (+)
LP/J MGP_LPJ_G0024064
 protein coding gene Chr18:8133309-8168295 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023975
 protein coding gene Chr18:8772142-8806891 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024604
 protein coding gene Chr18:7992627-8027724 (+)
PWK/PhJ MGP_PWKPhJ_G0023103
 protein coding gene Chr18:7850064-7884485 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022912
 protein coding gene Chr18:8163970-8196978 (+)
WSB/EiJ MGP_WSBEiJ_G0023423
 protein coding gene Chr18:7962730-7997964 (+)



Homology
more
  • Human Ortholog
    GATA6, GATA binding protein 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATA6, GATA binding protein 6
  • Links
    NCBI Gene ID: 2627
    neXtProt AC: NX_Q92908
    UniProt: Q92908

  • Chr Location
    18q11.2; chr18:22169589-22202528 (+)  GRCh38
Human Diseases
more
  • Diseases
    8 with human GATA6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 10 alleles in 13 genetic backgrounds
    42 phenotypes from multigenic genotypes
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant E5.5 embryos lack parts of the visceral endoderm, show impaired embryonic ectoderm development, and die soon post-implantation, apparently of extraembryonic tissue defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    132
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1653
  • Tissues
    398
  • cDNA Data
    52
  • Literature Summary
    248
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14465 NCBI Gene Model | MGI Sequence Detail 33127 C57BL/6J ±  kb
    transcript NM_010258 RefSeq | MGI Sequence Detail 3194 ZRU/MplStud  
    polypeptide Q61169 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 5
      cDNA 55
      Primer pair 23
      Other 10

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36086, MGI:2147171
    References
    more
    • Summaries
      All 372
      Developmental Gene Expression 248
      Gene Ontology 35
      Phenotypes 101
    • Earliest
      J:34197 Morrisey EE, et al., GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol. 1996 Jul 10;177(1):309-22
    • Latest
      J:355264 Festuccia N, et al., Nr5a2 is dispensable for zygotic genome activation but essential for morula development. Science. 2024 Oct 4;386(6717):eadg7325
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory