Art2b MGI Mouse Gene Detail - MGI:107545 - ADP-ribosyltransferase 2b

Symbol

Art2b
Name

ADP-ribosyltransferase 2b
Synonyms

ART2.2, Rt-6, Rt6, Rt6-2

Feature Type

protein coding gene
IDs

MGI:107545
NCBI Gene: 11872
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:101226177-101234807 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.61 cM
Mapping Data

5 experiments

SNPs within 2kb

286 from dbSNP Build 142
Strain Annotations

9
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107545	protein coding gene	Chr7:101224936-101234807 (-)
129S1/SvImJ	no annotation
A/J	MGP_AJ_G0032561	protein coding gene	Chr7:101901841-101903797 (-)
AKR/J	MGP_AKRJ_G0032497	protein coding gene	Chr7:104346802-104355838 (-)
BALB/cJ	MGP_BALBcJ_G0032572	protein coding gene	Chr7:101587961-101604611 (-)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0033069	protein coding gene	Chr7:108500764-108502558 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030063	protein coding gene	Chr7:104249422-104252048 (-)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0032404	protein coding gene	Chr7:100243232-100245018 (-)
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0033091	protein coding gene	Chr7:103572471-103579636 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0031174	protein coding gene	Chr7:90883397-90890743 (-)
WSB/EiJ	no annotation

Human Ortholog

ART2BP, ADP-ribosyltransferase 2B, pseudogene

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ART2BP, ADP-ribosyltransferase 2B, pseudogene
Synonyms

ARTC2BP
Links

HGNC:51489

NCBI Gene ID: 106481723
Chr Location

11q13.4; chr11:72478221-72479237 (+) GRCh38

MGI Vertebrate Homology

Art2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ART2BP
Gene Tree

Art2b

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Phenotype Summary

2 phenotypes from multigenic genotypes
23 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Art2b
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

11
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

27
RefSeq

6
UniProt

2
CCDS

CCDS21512.1

Ensembl

ENSMUSG00000030651 (Evidence)
NCBI Gene

11872

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030651	Ensembl Gene Model \| MGI Sequence Detail	8631	C57BL/6J	± kb
transcript	ENSMUST00000063920	Ensembl \| MGI Sequence Detail	870	Not Applicable
polypeptide	ENSMUSP00000065658	Ensembl \| MGI Sequence Detail	289	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004578 T-cell ecto-ADP-ribosyltransferase 2

(term hierarchy)
EC

2.4.2.31, 3.2.2.5
InterPro Domains

IPR050999 Arg-specific ADP-ribosyltransferase

IPR000768 NAD:arginine ADP-ribosyltransferase, ART
GlyGen

O35975 2 sites

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All nucleic 5

Genomic 1

cDNA 3

Other 1

Microarray probesets 3

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MGD-MRK-14246, MGD-MRK-18652, MGD-MRK-18653, MGD-MRK-36116

Summaries

All 55

Gene Ontology 10

Phenotypes 23
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:263067 Garcia-Rodriguez S, et al., CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism. Sci Rep. 2018 Feb 20;8(1):3357

TSS for Art2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73846	Chr7:101234800-101234814 (-)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24