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Irf9 Gene Detail
Summary
  • Symbol
    Irf9
  • Name
    interferon regulatory factor 9
  • Synonyms
    Irf-9, Isgf3g, p48
  • Feature Type
    protein coding gene
  • IDs
    MGI:107587
    NCBI Gene: 16391
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55841442-55847487 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107587
 protein coding gene Chr14:55841028-55847487 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021355
 protein coding gene Chr14:49640092-49648805 (+)
A/J MGP_AJ_G0021314
 protein coding gene Chr14:48651613-48658048 (+)
AKR/J MGP_AKRJ_G0021290
 protein coding gene Chr14:50397496-50403952 (+)
BALB/cJ MGP_BALBcJ_G0021318
 protein coding gene Chr14:48597401-48603840 (+)
C3H/HeJ MGP_C3HHeJ_G0021098
 protein coding gene Chr14:50082633-50089098 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021756
 protein coding gene Chr14:52134307-52140772 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019303
 protein coding gene Chr14:47026859-47033357 (+)
CAST/EiJ MGP_CASTEiJ_G0020617
 protein coding gene Chr14:46347264-46353738 (+)
CBA/J MGP_CBAJ_G0021065
 protein coding gene Chr14:53688218-53698190 (+)
DBA/2J MGP_DBA2J_G0021186
 protein coding gene Chr14:48376590-48383068 (+)
FVB/NJ MGP_FVBNJ_G0021168
 protein coding gene Chr14:47824513-47830972 (+)
LP/J MGP_LPJ_G0021260
 protein coding gene Chr14:50684051-50690488 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021192
 protein coding gene Chr14:53051198-53059121 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021783
 protein coding gene Chr14:49584821-49591294 (+)
PWK/PhJ MGP_PWKPhJ_G0020364
 protein coding gene Chr14:44908336-44914905 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020192
 protein coding gene Chr14:45589266-45597983 (+)
WSB/EiJ MGP_WSBEiJ_G0020670
 protein coding gene Chr14:49870958-49877430 (+)



Homology
more
  • Human Ortholog
    IRF9, interferon regulatory factor 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF9, interferon regulatory factor 9
  • Synonyms
    IRF-9, ISGF3, ISGF3G, p48
  • Links
    NCBI Gene ID: 10379
    neXtProt AC: NX_Q00978
    UniProt: Q00978

  • Chr Location
    14q12; chr14:24161234-24168043 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IRF9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, antivirus response induced by Ifn alfpha and Ifn gamma are impaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    191
  • cDNA Data
    70
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16391 NCBI Gene Model | MGI Sequence Detail 6046 C57BL/6J ±  kb
    transcript NM_001159417 RefSeq | MGI Sequence Detail 2545 ZRU/MplStud  
    polypeptide Q61179 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 71
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36159
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 55
    • Earliest
      J:22857 Kawakami T, et al., Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene. FEBS Lett. 1995 Jan 30;358(3):225-9
    • Latest
      J:349464 Fortelny N, et al., JAK-STAT signaling maintains homeostasis in T cells and macrophages. Nat Immunol. 2024 May;25(5):847-859
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory