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Sp4 Gene Detail
Summary
  • Symbol
    Sp4
  • Name
    trans-acting transcription factor 4
  • Synonyms
    5730497N03Rik, HF1-b, HF-1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:107595
    NCBI Gene: 20688
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:118198668-118265175 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 63.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107595
 protein coding gene Chr12:118195421-118265211 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020187
 protein coding gene Chr12:121202037-121274516 (-)
A/J MGP_AJ_G0020143
 protein coding gene Chr12:116720703-116790314 (-)
AKR/J MGP_AKRJ_G0020118
 protein coding gene Chr12:120260296-120328419 (-)
BALB/cJ MGP_BALBcJ_G0020126
 protein coding gene Chr12:117150584-117222959 (-)
C3H/HeJ MGP_C3HHeJ_G0019930
 protein coding gene Chr12:120560264-120633784 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020573
 protein coding gene Chr12:124986774-125058156 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018185
 protein coding gene Chr12:113100013-113167025 (-)
CAST/EiJ MGP_CASTEiJ_G0019470
 protein coding gene Chr12:114419684-114488968 (-)
CBA/J MGP_CBAJ_G0019897
 protein coding gene Chr12:129910588-129979984 (-)
DBA/2J MGP_DBA2J_G0020014
 protein coding gene Chr12:116120854-116194083 (-)
FVB/NJ MGP_FVBNJ_G0019999
 protein coding gene Chr12:114787727-114854147 (-)
LP/J MGP_LPJ_G0020088
 protein coding gene Chr12:121226370-121295964 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020035
 protein coding gene Chr12:133159793-133231633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020602
 protein coding gene Chr12:119437723-119504159 (-)
PWK/PhJ MGP_PWKPhJ_G0019232
 protein coding gene Chr12:110875246-110942925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019037
 protein coding gene Chr12:112393485-112461983 (-)
WSB/EiJ MGP_WSBEiJ_G0019528
 protein coding gene Chr12:120416016-120483362 (-)



Homology
more
  • Human Ortholog
    SP4, Sp4 transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SP4, Sp4 transcription factor
  • Synonyms
    HF1B, SPR-1
  • Links
    NCBI Gene ID: 6671
    neXtProt AC: NX_Q02446
    UniProt: Q02446

  • Chr Location
    7p15.3; chr7:21428043-21514822 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sp4 mouse models; 2 with human SP4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 6 alleles in 6 genetic backgrounds
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cardiac arrhythmias and most die shortly after birth. Surviving males complete spermatogenesis but do not copulate, while females show delayed sexual maturation and reduction in spleen, thymus, and uterus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    133
  • cDNA Data
    16
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025323 Ensembl Gene Model | MGI Sequence Detail 66508 C57BL/6J ±  kb
    transcript ENSMUST00000222314 Ensembl | MGI Sequence Detail 2677 Not Applicable  
    polypeptide ENSMUSP00000152603 Ensembl | MGI Sequence Detail 782 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36167, MGI:1917860
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 10
      Diseases 5
      Gene Ontology 7
      Phenotypes 81
    • Earliest
      J:33573 Supp DM, et al., Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol. 1996 Jun 15;176(2):284-99
    • Latest
      J:332407 Gu Y, et al., Multi-omics profiling visualizes dynamics of cardiac development and functions. Cell Rep. 2022 Dec 27;41(13):111891
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory