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Hrh1 Gene Detail
Summary
  • Symbol
    Hrh1
  • Name
    histamine receptor H1
  • Synonyms
    Bphs, Hir
  • Feature Type
    protein coding gene
  • IDs
    MGI:107619
    NCBI Gene: 15465
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:114374897-114459432 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.05 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2646 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107619
 protein coding gene Chr6:114374897-114460257 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031141
 protein coding gene Chr6:116975917-117061135 (+)
A/J MGP_AJ_G0031110
 protein coding gene Chr6:112483165-112569001 (+)
AKR/J MGP_AKRJ_G0031041
 protein coding gene Chr6:115505233-115597822 (+)
BALB/cJ MGP_BALBcJ_G0031121
 protein coding gene Chr6:112432003-112517198 (+)
C3H/HeJ MGP_C3HHeJ_G0030587
 protein coding gene Chr6:68707612-68794294 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031580
 protein coding gene Chr6:119970977-120056471 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028744
 protein coding gene Chr6:109506807-109594581 (+)
CAST/EiJ MGP_CASTEiJ_G0030228
 protein coding gene Chr6:115985578-116074312 (+)
CBA/J MGP_CBAJ_G0030807
 protein coding gene Chr6:124716863-124802398 (+)
DBA/2J MGP_DBA2J_G0030960
 protein coding gene Chr6:111558981-111644131 (+)
FVB/NJ MGP_FVBNJ_G0030914
 protein coding gene Chr6:110575125-110661356 (+)
LP/J MGP_LPJ_G0031040
 protein coding gene Chr6:116996070-117082628 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030948
 protein coding gene Chr6:128922711-129008854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031607
 protein coding gene Chr6:115526548-115613968 (+)
PWK/PhJ MGP_PWKPhJ_G0029944
 protein coding gene Chr6:110531721-110620025 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029772
 protein coding gene Chr6:114347553-114433523 (+)
WSB/EiJ MGP_WSBEiJ_G0030312
 protein coding gene Chr6:115904676-115994829 (+)



Homology
more
  • Human Ortholog
    HRH1, histamine receptor H1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HRH1, histamine receptor H1
  • Synonyms
    H1-R, H1R, HH1R, hisH1
  • Links
    NCBI Gene ID: 3269
    neXtProt AC: NX_P35367
    UniProt: P35367

  • Chr Location
    3p25.3; chr3:11137093-11263557 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 4 alleles in 6 genetic backgrounds
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show decrease in exploratory behavior, diurnal activity, aggression, anxiety, serotonin release, respiratory reaction to temperature and leptin response. Natural variants affect B. pertussis induced vasoactive amine sensitization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    12
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15465 NCBI Gene Model | MGI Sequence Detail 84536 C57BL/6J ±  kb
    transcript NM_001317126 RefSeq | MGI Sequence Detail 3081 ZRU/MplStud  
    polypeptide P70174 UniProt | EBI | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 4
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1616, MGD-MRK-36193, MGI:88188
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 85
    • Earliest
      J:4933 Sudweeks JD, et al., Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3700-4
    • Latest
      J:353069 Sung CYW, et al., Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity. Sci Adv. 2024 Jul 26;10(30):eadk9878
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory