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Prdm2 Gene Detail
Summary
  • Symbol
    Prdm2
  • Name
    PR domain containing 2, with ZNF domain
  • Synonyms
    4833427P12Rik, E330024L24Rik, KMT8, LOC381568, Riz, Riz1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107628
    NCBI Gene: 110593
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:142833961-142939560 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 76.84 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2507 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107628
 protein coding gene Chr4:142833961-142939565 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029065
 protein coding gene Chr4:146300091-146409135 (-)
A/J MGP_AJ_G0029025
 protein coding gene Chr4:139922791-140040795 (-)
AKR/J MGP_AKRJ_G0028977
 protein coding gene Chr4:143965882-144076531 (-)
BALB/cJ MGP_BALBcJ_G0029049
 protein coding gene Chr4:140599680-140708225 (-)
C3H/HeJ MGP_C3HHeJ_G0028763
 protein coding gene Chr4:144344958-144455540 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029490
 protein coding gene Chr4:151341206-151451466 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026760
 protein coding gene Chr4:132793152-132894628 (-)
CAST/EiJ MGP_CASTEiJ_G0028195
 protein coding gene Chr4:142640795-142754554 (-)
CBA/J MGP_CBAJ_G0028727
 protein coding gene Chr4:155880415-155990701 (-)
DBA/2J MGP_DBA2J_G0028877
 protein coding gene Chr4:140276827-140383920 (-)
FVB/NJ MGP_FVBNJ_G0028844
 protein coding gene Chr4:139446175-139554885 (-)
LP/J MGP_LPJ_G0028976
 protein coding gene Chr4:146326616-146441788 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028870
 protein coding gene Chr4:159510915-159633141 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029528
 protein coding gene Chr4:144510200-144624378 (-)
PWK/PhJ MGP_PWKPhJ_G0027916
 protein coding gene Chr4:137189761-137299286 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027740
 protein coding gene Chr4:140324544-140438086 (-)
WSB/EiJ MGP_WSBEiJ_G0028273
 protein coding gene Chr4:144780674-144891326 (-)



Homology
more
  • Human Ortholog
    PRDM2, PR/SET domain 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM2, PR/SET domain 2
  • Synonyms
    HUMHOXY1, KMT8, KMT8A, MTB-ZF, RIZ, RIZ1, RIZ2
  • Links
    NCBI Gene ID: 7799
    neXtProt AC: NX_Q13029
    UniProt: Q13029

  • Chr Location
    1p36.21; chr1:13700188-13825079 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have shortened life spans, becoming moribund due to increased incidence of tumors. Mice had a broad spectrum of unusual tumors in multiple organs, with a high incidence of diffuse large B cell lymphomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    20
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110593 NCBI Gene Model | MGI Sequence Detail 105600 C57BL/6J ±  kb
    transcript NM_001256380 RefSeq | MGI Sequence Detail 9410 ZRU/MplStud  
    polypeptide NP_001074824 RefSeq | MGI Sequence Detail 1709 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36202, MGI:1921838, MGI:2685879
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:40271 Buyse IM, et al., The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4467-71
    • Latest
      J:295457 Xie X, et al., Tumor suppressor RIZ1 in obesity and the PI3K/AKT/mTOR pathway. Obesity (Silver Spring). 2016 Feb;24(2):389-97
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory