Luzp1 MGI Mouse Gene Detail - MGI:107629 - leucine zipper protein 1

Symbol

Luzp1
Name

leucine zipper protein 1
Synonyms

2700072H04Rik, Luzp

Feature Type

protein coding gene
IDs

MGI:107629
NCBI Gene: 269593
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:136197072-136282091 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 68.80 cM
Mapping Data

3 experiments

SNPs within 2kb

1675 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107629	protein coding gene	Chr4:136189892-136282091 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028968	protein coding gene	Chr4:139044004-139133194 (+)
A/J	MGP_AJ_G0028927	protein coding gene	Chr4:133106860-133192426 (+)
AKR/J	MGP_AKRJ_G0028879	protein coding gene	Chr4:136951913-137039533 (+)
BALB/cJ	MGP_BALBcJ_G0028951	protein coding gene	Chr4:133768053-133861492 (+)
C3H/HeJ	MGP_C3HHeJ_G0028665	protein coding gene	Chr4:137243753-137328642 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029392	protein coding gene	Chr4:144009322-144098062 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026663	protein coding gene	Chr4:126141586-126231508 (+)
CAST/EiJ	MGP_CASTEiJ_G0028097	protein coding gene	Chr4:135389770-135484697 (+)
CBA/J	MGP_CBAJ_G0028630	protein coding gene	Chr4:147953351-148045923 (+)
DBA/2J	MGP_DBA2J_G0028779	protein coding gene	Chr4:133521563-133607097 (+)
FVB/NJ	MGP_FVBNJ_G0028746	protein coding gene	Chr4:132472204-132557333 (+)
LP/J	MGP_LPJ_G0028878	protein coding gene	Chr4:139126528-139213341 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028772	protein coding gene	Chr4:152127725-152217892 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029430	protein coding gene	Chr4:137435236-137523500 (+)
PWK/PhJ	MGP_PWKPhJ_G0027817	protein coding gene	Chr4:130305819-130390721 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027643	protein coding gene	Chr4:133224797-133313005 (+)
WSB/EiJ	MGP_WSBEiJ_G0028175	protein coding gene	Chr4:137589169-137676735 (+)

Human Ortholog

LUZP1, leucine zipper protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LUZP1, leucine zipper protein 1
Synonyms

LUZP
Links

HGNC:14985

NCBI Gene ID: 7798

neXtProt AC: NX_Q86V48

UniProt: Q86V48
Chr Location

1p36.12; chr1:23083642-23178152 (-) GRCh38

MGI Vertebrate Homology

Luzp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LUZP1
Gene Tree

Luzp1

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

60
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

53
Targeted

4
Genomic Mutations

3 involving Luzp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

77 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Gene inactivation causes defective neural tube closure (exencephaly) and massive apoptosis in the hindbrain. Despite the incomplete penetrance of NTD, all homozygotes die perinatally due to complex cardiovascular anomalies. Other defects include an eyelid fusion defect, omphalocele and cleft palate.

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

40
cDNA Data

23
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase luzp1

ZFIN luzp1

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All Sequences

69
RefSeq

10
UniProt

6
CCDS

CCDS38923.1

Ensembl

ENSMUSG00000001089 (Evidence)
NCBI Gene

269593

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001089	Ensembl Gene Model \| MGI Sequence Detail	85020	C57BL/6J	± kb
transcript	ENSMUST00000001116	Ensembl \| MGI Sequence Detail	7246	Not Applicable
polypeptide	ENSMUSP00000001116	Ensembl \| MGI Sequence Detail	1068	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009982 leucine zipper protein 1

(term hierarchy)
InterPro Domains

IPR050719 Cortactin-binding and Actin Dynamics Regulator
GlyGen

Q8R4U7 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 25

cDNA 23

Primer pair 2

Microarray probesets 7

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MGD-MRK-36203, MGI:1919863, MGI:2140218

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 14
Earliest

J:34242 Sun DS, et al., Identification, molecular characterization, and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein. Genomics. 1996 15;36(1):54-62
Latest

J:355672 Niri F, et al., Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1. Biochem Cell Biol. 2021 Dec;99(6):759-765

TSS for Luzp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39710	Chr4:136197066-136197126 (+)	24 bp
Tssr39711	Chr4:136207183-136207188 (+)	10,114 bp
Tssr39712	Chr4:136222908-136222912 (+)	25,838 bp
Tssr39713	Chr4:136265570-136265607 (+)	68,517 bp
Tssr39714	Chr4:136268255-136268278 (+)	71,195 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24