Lxn MGI Mouse Gene Detail - MGI:107633

Symbol

Lxn
Name

latexin

Feature Type

protein coding gene
IDs

MGI:107633
NCBI Gene: 17035
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:67365332-67371240 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 30.98 cM
Mapping Data

9 experiments

SNPs within 2kb

306 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107633	protein coding gene	Chr3:67365331-67371259 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027281	protein coding gene	Chr3:66614600-66620528 (-)
A/J	MGP_AJ_G0027243	protein coding gene	Chr3:64650269-64656197 (-)
AKR/J	MGP_AKRJ_G0027211	protein coding gene	Chr3:66047016-66052932 (-)
BALB/cJ	MGP_BALBcJ_G0027254	protein coding gene	Chr3:64525786-64531702 (-)
C3H/HeJ	MGP_C3HHeJ_G0026998	protein coding gene	Chr3:66287181-66293109 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027700	protein coding gene	Chr3:69104041-69109969 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025053	protein coding gene	Chr3:60980912-60986791 (-)
CAST/EiJ	MGP_CASTEiJ_G0026445	protein coding gene	Chr3:66233852-66239773 (-)
CBA/J	MGP_CBAJ_G0026973	protein coding gene	Chr3:71262880-71268796 (-)
DBA/2J	MGP_DBA2J_G0027109	protein coding gene	Chr3:64164020-64169936 (-)
FVB/NJ	MGP_FVBNJ_G0027077	protein coding gene	Chr3:62796620-62802536 (-)
LP/J	MGP_LPJ_G0027217	protein coding gene	Chr3:67537155-67543083 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027096	protein coding gene	Chr3:75919859-75925775 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027758	protein coding gene	Chr3:65923195-65929111 (-)
PWK/PhJ	MGP_PWKPhJ_G0026179	protein coding gene	Chr3:63901655-63907666 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025995	protein coding gene	Chr3:65027153-65033076 (-)
WSB/EiJ	MGP_WSBEiJ_G0026523	protein coding gene	Chr3:66037595-66043525 (-)

Human Ortholog

LXN, latexin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LXN, latexin
Synonyms

ECI, TCI
Links

HGNC:13347

NCBI Gene ID: 56925

neXtProt AC: NX_Q9BS40

UniProt: Q9BS40
Chr Location

3q25.32; chr3:158645822-158672648 (-) GRCh38

MGI Vertebrate Homology

Lxn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LXN
Protein SuperFamily

Prot_inh_latexin
Gene Tree

Lxn

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Lxn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available

Mice homozygous for a targeted null mutation display reduced sensitivity to acute thermal pain, which can be reversed by exogenous carboxypeptidase inhibitor.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

813
Tissues

22
cDNA Data

82
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lxn

ZFIN lxn

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS17397.1

Ensembl

ENSMUSG00000047557 (Evidence)
NCBI Gene

17035

			Length	Strain/Species	Flank
genomic	17035	NCBI Gene Model \| MGI Sequence Detail	5909	C57BL/6J	± kb
transcript	NM_016753	RefSeq \| MGI Sequence Detail	1092	ZRU/MplStud
polypeptide	P70202	UniProt \| EBI \| MGI Sequence Detail	222	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009987 latexin

(term hierarchy)
PDB

1WNH
InterPro Domains

IPR046350 Cystatin superfamily

IPR009684 Latexin

IPR049897 Latexin-type cystatin domain

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All nucleic 84

Genomic 1

cDNA 83

Microarray probesets 3

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MGD-MRK-36207

Summaries

All 52

Developmental Gene Expression 10

Diseases 1

Gene Ontology 4

Phenotypes 11
Earliest

J:37801 Jin M, et al., Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific manner. Genomics. 1997 Feb 1;39(3):419-21
Latest

J:357796 He G, et al., Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation. Cell Death Dis. 2024 Oct 18;15(10):754

TSS for Lxn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33501	Chr3:67371467-67371500 (-)	-244 bp
Tssr33500	Chr3:67371161-67371276 (-)	21 bp
Tssr33499	Chr3:67371131-67371158 (-)	95 bp
Tssr33498	Chr3:67371113-67371124 (-)	121 bp
Tssr33497	Chr3:67370949-67370960 (-)	285 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24