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Ifngr2 Gene Detail
Summary
  • Symbol
    Ifngr2
  • Name
    interferon gamma receptor 2
  • Synonyms
    Ifgr2, Ifgt
  • Feature Type
    protein coding gene
  • IDs
    MGI:107654
    NCBI Gene: 15980
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91343947-91360895 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 53.07 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    640 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107654
 protein coding gene Chr16:91343947-91362511 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023042
 protein coding gene Chr16:92568698-92586422 (+)
A/J MGP_AJ_G0023010
 protein coding gene Chr16:88240821-88258802 (+)
AKR/J MGP_AKRJ_G0022980
 protein coding gene Chr16:90902616-90920713 (+)
BALB/cJ MGP_BALBcJ_G0023012
 protein coding gene Chr16:88765982-88785231 (+)
C3H/HeJ MGP_C3HHeJ_G0022773
 protein coding gene Chr16:91478361-91500622 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023459
 protein coding gene Chr16:95558060-95578329 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020961
 protein coding gene Chr16:85931667-85951541 (+)
CAST/EiJ MGP_CASTEiJ_G0022292
 protein coding gene Chr16:92040286-92061353 (+)
CBA/J MGP_CBAJ_G0022742
 protein coding gene Chr16:99634447-99658217 (+)
DBA/2J MGP_DBA2J_G0022876
 protein coding gene Chr16:88141841-88160011 (+)
FVB/NJ MGP_FVBNJ_G0022850
 protein coding gene Chr16:87269263-87287893 (+)
LP/J MGP_LPJ_G0022946
 protein coding gene Chr16:92272545-92290903 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022871
 protein coding gene Chr16:104190004-104211391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023477
 protein coding gene Chr16:91424369-91442614 (+)
PWK/PhJ MGP_PWKPhJ_G0022037
 protein coding gene Chr16:88317371-88337069 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021867
 protein coding gene Chr16:90985290-91003270 (+)
WSB/EiJ MGP_WSBEiJ_G0022344
 protein coding gene Chr16:91666720-91686167 (+)



Homology
more
  • Human Ortholog
    IFNGR2, interferon gamma receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNGR2, interferon gamma receptor 2
  • Synonyms
    AF-1, IFGR2, IFNGT1, IMD28
  • Links
    NCBI Gene ID: 3460
    neXtProt AC: NX_P38484
    UniProt: P38484

  • Chr Location
    21q22.11; chr21:33402882-33479348 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ifngr2 mouse models; 1 with human IFNGR2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 5 genetic backgrounds
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene develop normally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    952
  • Tissues
    158
  • cDNA Data
    56
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15980 NCBI Gene Model | MGI Sequence Detail 16949 C57BL/6J ±  kb
    transcript NM_008338 RefSeq | MGI Sequence Detail 2105 ZRU/MplStud  
    polypeptide NP_032364 RefSeq | MGI Sequence Detail 332 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR015373 Interferon/interleukin receptor domain
      IPR050650 Type II Cytokine and Tissue Factor Receptors
    • GlyGen
      Q63953 4 sites, 5 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 57
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11216, MGD-MRK-25614, MGD-MRK-36229
    References
    more
    • Summaries
      All 157
      Developmental Gene Expression 7
      Diseases 5
      Gene Ontology 4
      Phenotypes 109
    • Earliest
      J:11127 Hibino Y, et al., Expression and reconstitution of a biologically active mouse interferon gamma receptor in hamster cells. Chromosomal location of an accessory factor. J Biol Chem. 1991 Apr 15;266(11):6948-51
    • Latest
      J:352331 Martin AT, et al., Parasite-induced IFN-gamma regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death. PLoS Pathog. 2024 Feb;20(2):e1011502
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory