Ifnar1 MGI Mouse Gene Detail - MGI:107658 - interferon (alpha and beta) receptor 1

Symbol

Ifnar1
Name

interferon (alpha and beta) receptor 1
Synonyms

Ifar, IFN-alpha/betaR, Ifrc

Feature Type

protein coding gene
IDs

MGI:107658
NCBI Gene: 15975
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr16:91282126-91304329 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 52.98 cM
Mapping Data

13 experiments

SNPs within 2kb

523 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107658	protein coding gene	Chr16:91281016-91307411 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023041	protein coding gene	Chr16:92495892-92518051 (+)
A/J	MGP_AJ_G0023009	protein coding gene	Chr16:88179235-88201613 (+)
AKR/J	MGP_AKRJ_G0022979	protein coding gene	Chr16:90832309-90857183 (+)
BALB/cJ	MGP_BALBcJ_G0023011	protein coding gene	Chr16:88702612-88725846 (+)
C3H/HeJ	MGP_C3HHeJ_G0022772	protein coding gene	Chr16:91413483-91436907 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023458	protein coding gene	Chr16:95493907-95515401 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020960	protein coding gene	Chr16:85873776-85892556 (+)
CAST/EiJ	MGP_CASTEiJ_G0022291	protein coding gene	Chr16:91969988-91994173 (+)
CBA/J	MGP_CBAJ_G0022741	protein coding gene	Chr16:99564437-99592463 (+)
DBA/2J	MGP_DBA2J_G0022875	protein coding gene	Chr16:88075311-88097816 (+)
FVB/NJ	MGP_FVBNJ_G0022849	protein coding gene	Chr16:87205605-87227415 (+)
LP/J	MGP_LPJ_G0022945	protein coding gene	Chr16:92207876-92230495 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022870	protein coding gene	Chr16:104121606-104144280 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023476	protein coding gene	Chr16:91356816-91379613 (+)
PWK/PhJ	MGP_PWKPhJ_G0022036	protein coding gene	Chr16:88251647-88274215 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021866	protein coding gene	Chr16:90898557-90924053 (+)
WSB/EiJ	MGP_WSBEiJ_G0022343	protein coding gene	Chr16:91597180-91619862 (+)

Human Ortholog

IFNAR1, interferon alpha and beta receptor subunit 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFNAR1, interferon alpha and beta receptor subunit 1
Synonyms

AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, IMD106
Links

HGNC:5432

NCBI Gene ID: 3454

neXtProt AC: NX_P17181

UniProt: P17181
Chr Location

21q22.11; chr21:33324387-33359864 (+) GRCh38

MGI Vertebrate Homology

Ifnar1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IFNAR1
Protein SuperFamily

IFN_alpha/beta_recept-1
Gene Tree

Ifnar1

Diseases

2 with human IFNAR1 associations

				Human Disease	Mouse Models
				hepatitis C IDs hepatitis C DOID:1883 DOID:12430 DOID:12432 DOID:2049 EFO:0003047 ICD10CM:B19.20 ICD9CM:070.7 MESH:D006526 NCI:C3098 UMLS_CUI:C0019196
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

7 with disease annotations

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Phenotype Summary

58 phenotypes from 5 alleles in 10 genetic backgrounds
67 phenotypes from multigenic genotypes
1468 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (ENU)

2
Endonuclease-mediated

13
Gene trapped

4
Spontaneous

1
Targeted

15
Genomic Mutations

10 involving Ifnar1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.

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All GO Annotations

34
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1070
Tissues

201
cDNA Data

101
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ifnar1

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All Sequences

72
RefSeq

3
UniProt

8
CCDS

CCDS28326.1

Ensembl

ENSMUSG00000022967 (Evidence)
NCBI Gene

15975

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022967	Ensembl Gene Model \| MGI Sequence Detail	22204	C57BL/6J	± kb
transcript	ENSMUST00000023689	Ensembl \| MGI Sequence Detail	3909	Not Applicable
polypeptide	ENSMUSP00000023689	Ensembl \| MGI Sequence Detail	590	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000008922 interferon-alpha/beta receptor alpha chain

(term hierarchy)
PDB

3WCY
EC

6.3.4.13
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR016669 Interferon alpha/beta receptor 1

IPR015373 Interferon/interleukin receptor domain

IPR050650 Type II Cytokine and Tissue Factor Receptors
GlyGen

P33896 8 sites, 2 N-linked glycans (2 sites)

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All nucleic 106

Genomic 2

cDNA 101

Primer pair 1

Other 2

Microarray probesets 4

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MGD-MRK-11211, MGD-MRK-11223, MGD-MRK-36233

Summaries

All 1637

Developmental Gene Expression 9

Diseases 7

Gene Ontology 15

Phenotypes 1468
Earliest

J:6319 Cox DR, et al., Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2168-72
Latest

J:357414 Porier DL, et al., Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate. PLoS Pathog. 2024 Oct;20(10):e1012566

TSS for Ifnar1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139396	Chr16:91281941-91281954 (+)	-178 bp
Tssr139397	Chr16:91281955-91281993 (+)	-152 bp
Tssr139398	Chr16:91282003-91282032 (+)	-108 bp
Tssr139399	Chr16:91282121-91282182 (+)	26 bp
Tssr139400	Chr16:91282183-91282197 (+)	64 bp
Tssr139401	Chr16:91286582-91286595 (+)	4,463 bp
Tssr139402	Chr16:91289524-91289546 (+)	7,409 bp
Tssr139403	Chr16:91303069-91303113 (+)	20,965 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24