Myo1f MGI Mouse Gene Detail - MGI:107711

Symbol

Myo1f
Name

myosin IF
Synonyms

C330006B10Rik

Feature Type

protein coding gene
IDs

MGI:107711
NCBI Gene: 17916
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr17:33774681-33826738 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM, cytoband B-C
Mapping Data

6 experiments

SNPs within 2kb

1426 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107711	protein coding gene	Chr17:33774681-33826738 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023530	protein coding gene	Chr17:33474492-33529544 (+)
A/J	MGP_AJ_G0023489	protein coding gene	Chr17:32332301-32381267 (+)
AKR/J	MGP_AKRJ_G0023455	protein coding gene	Chr17:32706839-32758333 (+)
BALB/cJ	MGP_BALBcJ_G0023493	protein coding gene	Chr17:32477189-32529212 (+)
C3H/HeJ	MGP_C3HHeJ_G0023256	protein coding gene	Chr17:33043551-33097634 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023937	protein coding gene	Chr17:34700319-34761404 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021410	protein coding gene	Chr17:29861465-29911901 (+)
CAST/EiJ	MGP_CASTEiJ_G0022758	protein coding gene	Chr17:33163255-33217957 (+)
CBA/J	MGP_CBAJ_G0023232	protein coding gene	Chr17:36108291-36174173 (+)
DBA/2J	MGP_DBA2J_G0023361	protein coding gene	Chr17:31721741-31773127 (+)
FVB/NJ	MGP_FVBNJ_G0023330	protein coding gene	Chr17:31561600-31615311 (+)
LP/J	MGP_LPJ_G0023439	protein coding gene	Chr17:33759603-33816108 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023350	protein coding gene	Chr17:35173866-35233956 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023977	protein coding gene	Chr17:33032577-33084815 (+)
PWK/PhJ	MGP_PWKPhJ_G0022506	protein coding gene	Chr17:30613180-30664868 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022322	protein coding gene	Chr17:31004534-31062025 (+)
WSB/EiJ	MGP_WSBEiJ_G0022817	protein coding gene	Chr17:33079681-33132056 (+)

Human Ortholog

MYO1F, myosin IF

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO1F, myosin IF
Links

HGNC:7600

NCBI Gene ID: 4542

neXtProt AC: NX_O00160

UniProt: O00160
Chr Location

19p13.2; chr19:8520778-8577442 (-) GRCh38

MGI Vertebrate Homology

Myo1f stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MYO1F
Gene Tree

Myo1f

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Gene trapped

7
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

66 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion.

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All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

10
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myo1f

ZFIN myo1f

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All Sequences

48
RefSeq

2
UniProt

8
CCDS

CCDS37567.1

Ensembl

ENSMUSG00000024300 (Evidence)
NCBI Gene

17916

			Length	Strain/Species	Flank
genomic	17916	NCBI Gene Model \| MGI Sequence Detail	52058	C57BL/6J	± kb
transcript	NM_053214	RefSeq \| MGI Sequence Detail	3833	ZRU/MplStud
polypeptide	P70248	UniProt \| EBI \| MGI Sequence Detail	1099	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000010860 myosin-If

(term hierarchy)
InterPro Domains

IPR036072 Class I myosin, motor domain

IPR010926 Class I myosin tail homology domain

IPR050384 Endophilin/SH3RF

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR035507 Unconventional myosin-Ie/If, SH3 domain

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 5

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MGD-MRK-36287, MGI:2148238

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 15
Earliest

J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
Latest

J:346316 Martinez-Vargas IU, et al., Myo1f has an essential role in gammadeltaT intraepithelial lymphocyte adhesion and migration. Front Immunol. 2023;14:1041079

TSS for Myo1f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143763	Chr17:33774701-33774770 (+)	55 bp
Tssr143764	Chr17:33775339-33775352 (+)	665 bp
Tssr143765	Chr17:33775359-33775378 (+)	688 bp
Tssr143766	Chr17:33776165-33776179 (+)	1,491 bp
Tssr143767	Chr17:33776731-33776780 (+)	2,075 bp
Tssr143768	Chr17:33777821-33777836 (+)	3,148 bp
Tssr143769	Chr17:33795581-33795614 (+)	20,917 bp
Tssr143770	Chr17:33796881-33796883 (+)	22,201 bp
Tssr143771	Chr17:33797109-33797118 (+)	22,433 bp
Tssr143772	Chr17:33803264-33803276 (+)	28,589 bp
Tssr143773	Chr17:33803296-33803336 (+)	28,635 bp
Tssr143774	Chr17:33806304-33806327 (+)	31,635 bp
Tssr143775	Chr17:33810219-33810231 (+)	35,544 bp
Tssr143776	Chr17:33813468-33813480 (+)	38,793 bp
Tssr143777	Chr17:33813515-33813522 (+)	38,838 bp
Tssr143778	Chr17:33819682-33819726 (+)	45,023 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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