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Neurog1 Gene Detail
Summary
  • Symbol
    Neurog1
  • Name
    neurogenin 1
  • Synonyms
    bHLHa6, Math4C, Neurod3, neurogenin, neurogenin 1, ngn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107754
    NCBI Gene: 18014
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56398291-56399976 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107754
 protein coding gene Chr13:56398291-56399993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020615
 protein coding gene Chr13:55787526-55790186 (-)
A/J MGP_AJ_G0020569
 protein coding gene Chr13:53717906-53719562 (-)
AKR/J MGP_AKRJ_G0020547
 protein coding gene Chr13:55310764-55312432 (-)
BALB/cJ MGP_BALBcJ_G0020565
 protein coding gene Chr13:53950182-53951809 (-)
C3H/HeJ MGP_C3HHeJ_G0020364
 protein coding gene Chr13:55117646-55119310 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020999
 protein coding gene Chr13:57484331-57485998 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018581
 protein coding gene Chr13:51648364-51650024 (-)
CAST/EiJ MGP_CASTEiJ_G0019878
 protein coding gene Chr13:55231329-55232995 (-)
CBA/J MGP_CBAJ_G0020324
 protein coding gene Chr13:59671487-59673128 (-)
DBA/2J MGP_DBA2J_G0020447
 protein coding gene Chr13:53264529-53266170 (-)
FVB/NJ MGP_FVBNJ_G0020426
 protein coding gene Chr13:52732420-52734522 (-)
LP/J MGP_LPJ_G0020523
 protein coding gene Chr13:56045682-56047301 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020455
 protein coding gene Chr13:59094911-59096537 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021042
 protein coding gene Chr13:54899538-54901181 (-)
PWK/PhJ MGP_PWKPhJ_G0019634
 protein coding gene Chr13:53295141-53296817 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019461
 protein coding gene Chr13:53826719-53830391 (-)
WSB/EiJ MGP_WSBEiJ_G0019940
 protein coding gene Chr13:55256991-55259619 (-)



Homology
more
  • Human Ortholog
    NEUROG1, neurogenin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROG1, neurogenin 1
  • Synonyms
    AKA, bHLHa6, CCDDRD, Math4C, NEUROD3, ngn1
  • Links
    NCBI Gene ID: 4762
    neXtProt AC: NX_Q92886
    UniProt: Q92886

  • Chr Location
    5q31.1; chr5:135534282-135535964 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects in midbrain, dorsal root sensory ganglia and a subset of cranial ganglia. Mutants are born alive, but fail to nurse, and die within 12 hours.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1335
  • Tissues
    298
  • cDNA Data
    17
  • Literature Summary
    228
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048904 Ensembl Gene Model | MGI Sequence Detail 1686 C57BL/6J ±  kb
    transcript ENSMUST00000058475 Ensembl | MGI Sequence Detail 1686 Not Applicable  
    polypeptide ENSMUSP00000050484 Ensembl | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 7
      cDNA 20
      Primer pair 13
      Other 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36330
    References
    more
    • Summaries
      All 296
      Developmental Gene Expression 228
      Gene Ontology 14
      Phenotypes 53
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:354180 Xu M, et al., ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons. J Neurosci. 2024 Feb 21;44(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory