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Neurod2 Gene Detail
Summary
  • Symbol
    Neurod2
  • Name
    neurogenic differentiation 2
  • Synonyms
    bHLHa1, Ndrf
  • Feature Type
    protein coding gene
  • IDs
    MGI:107755
    NCBI Gene: 18013
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98216241-98220471 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.75 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107755
 protein coding gene Chr11:98216241-98220474 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019053
 protein coding gene Chr11:100855465-100859688 (-)
A/J MGP_AJ_G0019021
 protein coding gene Chr11:96672242-96676475 (-)
AKR/J MGP_AKRJ_G0018991
 protein coding gene Chr11:99663330-99667563 (-)
BALB/cJ MGP_BALBcJ_G0018994
 protein coding gene Chr11:97162678-97166911 (-)
C3H/HeJ MGP_C3HHeJ_G0018808
 protein coding gene Chr11:99796495-99800718 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019447
 protein coding gene Chr11:103936262-103940495 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017078
 protein coding gene Chr11:94111426-94115674 (-)
CAST/EiJ MGP_CASTEiJ_G0018362
 protein coding gene Chr11:100671305-100675545 (-)
CBA/J MGP_CBAJ_G0018779
 protein coding gene Chr11:108254294-108258527 (-)
DBA/2J MGP_DBA2J_G0018887
 protein coding gene Chr11:96212753-96216976 (-)
FVB/NJ MGP_FVBNJ_G0018876
 protein coding gene Chr11:95722030-95726253 (-)
LP/J MGP_LPJ_G0018957
 protein coding gene Chr11:101334484-101338707 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018903
 protein coding gene Chr11:108054960-108059195 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019487
 protein coding gene Chr11:99993601-99997826 (-)
PWK/PhJ MGP_PWKPhJ_G0018134
 protein coding gene Chr11:97217956-97222202 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017924
 protein coding gene Chr11:99700037-99704261 (-)
WSB/EiJ MGP_WSBEiJ_G0018412
 protein coding gene Chr11:99896464-99900699 (-)



Homology
more
  • Human Ortholog
    NEUROD2, neuronal differentiation 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROD2, neuronal differentiation 2
  • Synonyms
    bHLHa1, DEE72, EIEE72, NDRF
  • Links
    NCBI Gene ID: 4761
    neXtProt AC: NX_Q15784
    UniProt: Q15784

  • Chr Location
    17q12; chr17:39603536-39609777 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NEUROD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation show elevated neuronal apoptosis resulting in ataxia, incoordination, elevated seizure susceptibility, and death by 35 days. Heterozygotes are moderately affected, and adults are subject to unexplained death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    108
  • cDNA Data
    26
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18013 NCBI Gene Model | MGI Sequence Detail 4231 C57BL/6J ±  kb
    transcript NM_010895 RefSeq | MGI Sequence Detail 3137 ZRU/MplStud  
    polypeptide Q62414 UniProt | EBI | MGI Sequence Detail 383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011153 neurogenic differentiation factor 2
      (term hierarchy)
    • InterPro Domains
      IPR050359 Basic helix-loop-helix transcription factors
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR022575 Neurogenic differentiation factor, domain of unknown function
      IPR016637 Neurogenic differentiation factor NeuroD
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 26
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33898, MGD-MRK-36331
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 50
      Gene Ontology 11
      Phenotypes 26
    • Earliest
      J:32452 Yasunami M, et al., Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Biochem Biophys Res Commun. 1996 Mar 27;220(3):754-8
    • Latest
      J:353337 Ma Q, et al., A single-cell transcriptomic landscape of cadmium-hindered brain development in mice. Commun Biol. 2024 Aug 15;7(1):997
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory