About   Help   FAQ
Tubb5 Gene Detail
Summary
  • Symbol
    Tubb5
  • Name
    tubulin, beta 5 class I
  • Synonyms
    B130022C14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107812
    NCBI Gene: 22154
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36144812-36149193 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107812
 protein coding gene Chr17:36144812-36149198 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023654
 protein coding gene Chr17:36028577-36032962 (-)
A/J MGP_AJ_G0023609
 protein coding gene Chr17:34913769-34918145 (-)
AKR/J MGP_AKRJ_G0023579
 protein coding gene Chr17:35339717-35344102 (-)
BALB/cJ MGP_BALBcJ_G0023614
 protein coding gene Chr17:35057854-35062230 (-)
C3H/HeJ MGP_C3HHeJ_G0023380
 protein coding gene Chr17:35805048-35809433 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024056
 protein coding gene Chr17:37499978-37504313 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021534
 protein coding gene Chr17:32609735-32614150 (-)
CAST/EiJ MGP_CASTEiJ_G0022871
 protein coding gene Chr17:35916075-35920457 (-)
CBA/J MGP_CBAJ_G0023358
 protein coding gene Chr17:39081459-39085839 (-)
DBA/2J MGP_DBA2J_G0023482
 protein coding gene Chr17:34220173-34224551 (-)
FVB/NJ MGP_FVBNJ_G0023453
 protein coding gene Chr17:34016421-34021049 (-)
LP/J MGP_LPJ_G0023562
 protein coding gene Chr17:36409115-36413503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023474
 protein coding gene Chr17:37849678-37854074 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024099
 protein coding gene Chr17:35654736-35659107 (-)
PWK/PhJ MGP_PWKPhJ_G0022622
 protein coding gene Chr17:33081520-33085932 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022441
 protein coding gene Chr17:33706097-33710382 (-)
WSB/EiJ MGP_WSBEiJ_G0022937
 protein coding gene Chr17:35802876-35807259 (-)



Homology
more
  • Human Ortholog
    TUBB, tubulin beta class I
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBB, tubulin beta class I
  • Synonyms
    CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5
  • Links
    NCBI Gene ID: 203068
    neXtProt AC: NX_P07437
    UniProt: P07437

  • Chr Location
    6p21.33; chr6:30717435-30725538 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tubb5 mouse models; 2 with human TUBB associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional knock-in or knock-out allele exhibit microcephaly due to upper-layer loss, delayed cell cycle progression and apoptosis of neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    100
  • cDNA Data
    45
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22154 NCBI Gene Model | MGI Sequence Detail 4382 C57BL/6J ±  kb
    transcript NM_011655 RefSeq | MGI Sequence Detail 2645 C57BL/6  
    polypeptide P99024 UniProt | EBI | MGI Sequence Detail 444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 46
      Primer pair 6
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36389, MGI:2146752, MGI:2146893, MGI:2442353
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:19085 Lewis SA, et al., Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 1985 Sep;101(3):852-61
    • Latest
      J:344223 Zhang W, et al., NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Cell Rep. 2023 Dec 26;42(12):113531
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory