Serpina5 MGI Mouse Gene Detail - MGI:107817 - serine (or cysteine) peptidase inhibitor, clade A, member 5

Symbol

Serpina5
Name

serine (or cysteine) peptidase inhibitor, clade A, member 5
Synonyms

alpha-1 antiproteinase, antitrypsin, PAI-3, Pci

Feature Type

protein coding gene
IDs

MGI:107817
NCBI Gene: 268591
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:104067372-104072396 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 53.30 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

388 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107817	protein coding gene	Chr12:104065572-104072397 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020066	protein coding gene	Chr12:105858611-105863616 (+)
A/J	MGP_AJ_G0020020	protein coding gene	Chr12:101866968-101871992 (+)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0020006	protein coding gene	Chr12:102156409-102167060 (+)
C3H/HeJ	MGP_C3HHeJ_G0019810	protein coding gene	Chr12:105233503-105238572 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020453	protein coding gene	Chr12:109171293-109176338 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018069	protein coding gene	Chr12:98533709-98548217 (+)
CAST/EiJ	MGP_CASTEiJ_G0019350	protein coding gene	Chr12:99967896-99979901 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0019893	protein coding gene	Chr12:101278681-101287444 (+)
FVB/NJ	MGP_FVBNJ_G0019879	protein coding gene	Chr12:100102565-100122548 (+)
LP/J	MGP_LPJ_G0019968	protein coding gene	Chr12:105698601-105705024 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019917	protein coding gene	Chr12:116656818-116669515 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020481	protein coding gene	Chr12:104212192-104217142 (+)
PWK/PhJ	MGP_PWKPhJ_G0019114	protein coding gene	Chr12:95847454-95852527 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018914	protein coding gene	Chr12:98413527-98418539 (+)
WSB/EiJ	MGP_WSBEiJ_G0019409	protein coding gene	Chr12:105062590-105072280 (+)

Human Ortholog

SERPINA5, serpin family A member 5

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINA5, serpin family A member 5
Synonyms

PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI
Links

HGNC:8723

NCBI Gene ID: 5104

neXtProt AC: NX_P05154

UniProt: P05154
Chr Location

14q32.13; chr14:94561442-94593118 (+) GRCh38

MGI Vertebrate Homology

Serpina5 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: SERPINA5
Gene Tree

Serpina5

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

1 involving Serpina5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene are phenotypically normal with the exception that males are infertile.

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All GO Annotations

52
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

54
cDNA Data

10
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

4
UniProt

2
CCDS

CCDS26146.1

Ensembl

ENSMUSG00000041550 (Evidence)
NCBI Gene

268591

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041550	Ensembl Gene Model \| MGI Sequence Detail	5025	C57BL/6J	± kb
transcript	ENSMUST00000021495	Ensembl \| MGI Sequence Detail	2162	Not Applicable
polypeptide	ENSMUSP00000021495	Ensembl \| MGI Sequence Detail	405	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014685 plasma serine protease inhibitor

(term hierarchy)
InterPro Domains

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2
GlyGen

P70458 1 site

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All nucleic 13

Genomic 3

cDNA 10

Microarray probesets 5

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MGD-MRK-36394

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 11
Earliest

J:34281 Zechmeister-Machhart M, et al., Molecular cloning and tissue distribution of mouse protein C inhibitor (PCI). Immunopharmacology. 1996 May;32(1-3):96-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Serpina5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114826	Chr12:104067241-104067257 (+)	-123 bp
Tssr114827	Chr12:104067279-104067287 (+)	-89 bp
Tssr114828	Chr12:104067346-104067357 (+)	-20 bp
Tssr114829	Chr12:104067401-104067416 (+)	37 bp
Tssr114830	Chr12:104067419-104067428 (+)	52 bp
Tssr114831	Chr12:104067432-104067435 (+)	62 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24