Mrc2 MGI Mouse Gene Detail - MGI:107818 - mannose receptor, C type 2

Symbol

Mrc2
Name

mannose receptor, C type 2
Synonyms

Endo180, mKIAA0709, novel lectin, uPARAP

Feature Type

protein coding gene
IDs

MGI:107818
NCBI Gene: 17534
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:105183469-105241965 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.73 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

1562 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107818	protein coding gene	Chr11:105183440-105241971 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019284	protein coding gene	Chr11:108519833-108586037 (+)
A/J	MGP_AJ_G0019252	protein coding gene	Chr11:103891722-103951830 (+)
AKR/J	MGP_AKRJ_G0019221	protein coding gene	Chr11:107029793-107087842 (+)
BALB/cJ	MGP_BALBcJ_G0019226	protein coding gene	Chr11:104311740-104372354 (+)
C3H/HeJ	MGP_C3HHeJ_G0019035	protein coding gene	Chr11:107313837-107376234 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019676	protein coding gene	Chr11:111888156-111953301 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017301	protein coding gene	Chr11:101229553-101288832 (+)
CAST/EiJ	MGP_CASTEiJ_G0018588	protein coding gene	Chr11:108361588-108423830 (+)
CBA/J	MGP_CBAJ_G0019004	protein coding gene	Chr11:116526683-116591347 (+)
DBA/2J	MGP_DBA2J_G0019116	protein coding gene	Chr11:103383441-103442231 (+)
FVB/NJ	MGP_FVBNJ_G0019107	protein coding gene	Chr11:102896476-102959054 (+)
LP/J	MGP_LPJ_G0019186	protein coding gene	Chr11:108990849-109054122 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019137	protein coding gene	Chr11:115797637-115864658 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019713	protein coding gene	Chr11:107506039-107564033 (+)
PWK/PhJ	MGP_PWKPhJ_G0018353	protein coding gene	Chr11:104471271-104535738 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018144	protein coding gene	Chr11:107257505-107319988 (+)
WSB/EiJ	MGP_WSBEiJ_G0018639	protein coding gene	Chr11:107470150-107535492 (+)

Human Ortholog

MRC2, mannose receptor C-type 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRC2, mannose receptor C-type 2
Synonyms

CD280, CLEC13E, ENDO180, UPARAP
Links

HGNC:16875

NCBI Gene ID: 9902

neXtProt AC: NX_Q9UBG0

UniProt: Q9UBG0
Chr Location

17q23.2; chr17:62627670-62693597 (+) GRCh38

MGI Vertebrate Homology

Mrc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRC2
Gene Tree

Mrc2

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

120 strains or lines available

Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

921
Tissues

47
cDNA Data

57
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrc2

ZFIN mrc2

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All Sequences

41
RefSeq

4
UniProt

3
CCDS

CCDS25539.1

Ensembl

ENSMUSG00000020695 (Evidence)
NCBI Gene

17534

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020695	Ensembl Gene Model \| MGI Sequence Detail	58497	C57BL/6J	± kb
transcript	ENSMUST00000100335	Ensembl \| MGI Sequence Detail	5795	Not Applicable
polypeptide	ENSMUSP00000097909	Ensembl \| MGI Sequence Detail	1479	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010561 C-type mannose receptor 2

(term hierarchy)
InterPro Domains

IPR033989 CD209-like, C-type lectin-like domain

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR000562 Fibronectin type II domain

IPR036943 Fibronectin type II domain superfamily

IPR013806 Kringle-like fold

IPR000772 Ricin B, lectin domain

IPR035992 Ricin B-like lectins
GlyGen

Q64449 13 sites, 8 N-linked glycans (7 sites), 1 O-linked glycan (3 sites)

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All nucleic 62

Genomic 1

cDNA 59

Primer pair 2

Microarray probesets 5

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MGD-MRK-36395

Summaries

All 65

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 27
Earliest

J:35139 Wu K, et al., Characterization of a novel member of the macrophage mannose receptor type C lectin family. J Biol Chem. 1996 Aug 30;271(35):21323-30
Latest

J:327900 Jenkins L, et al., Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade. Cancer Res. 2022 Aug 16;82(16):2904-2917

TSS for Mrc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105434	Chr11:105182937-105182979 (+)	-511 bp
Tssr105435	Chr11:105183448-105183455 (+)	-17 bp
Tssr105436	Chr11:105183463-105183495 (+)	10 bp
Tssr105437	Chr11:105183503-105183518 (+)	42 bp
Tssr105438	Chr11:105183525-105183540 (+)	64 bp
Tssr105439	Chr11:105195211-105195215 (+)	11,744 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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