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Pip5k1b Gene Detail
Summary
  • Symbol
    Pip5k1b
  • Name
    phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
  • Synonyms
    Pipk5b
  • Feature Type
    protein coding gene
  • IDs
    MGI:107930
    NCBI Gene: 18719
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:24272158-24533236 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 19.44 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8494 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107930
 protein coding gene Chr19:24272158-24533236 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024994
 protein coding gene Chr19:22516866-22795155 (-)
A/J MGP_AJ_G0024971
 protein coding gene Chr19:21278242-21538895 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0024970
 protein coding gene Chr19:21327998-21595599 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0025411
 protein coding gene Chr19:23226262-23513080 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022830
 protein coding gene Chr19:21447237-21625884 (-)
CAST/EiJ MGP_CASTEiJ_G0024196
 protein coding gene Chr19:21798725-22071271 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0024798
 protein coding gene Chr19:21154037-21423439 (-)
LP/J MGP_LPJ_G0024921
 protein coding gene Chr19:22470120-22745286 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024825
 protein coding gene Chr19:24268333-24542546 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025466
 protein coding gene Chr19:22101776-22376075 (-)
PWK/PhJ MGP_PWKPhJ_G0023944
 protein coding gene Chr19:20887996-21154923 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023749
 protein coding gene Chr19:21330848-21603025 (-)
WSB/EiJ MGP_WSBEiJ_G0024263
 protein coding gene Chr19:22128668-22399729 (-)



Homology
more
  • Human Ortholog
    PIP5K1B, phosphatidylinositol-4-phosphate 5-kinase type 1 beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIP5K1B, phosphatidylinositol-4-phosphate 5-kinase type 1 beta
  • Synonyms
    MSS4, STM7
  • Links
    NCBI Gene ID: 8395
    neXtProt AC: NX_O14986
    UniProt: O14986

  • Chr Location
    9q21.11; chr9:68705240-69009176 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced passive cutaneous and systemic anaphylaxis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    899
  • Tissues
    137
  • cDNA Data
    25
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18719 NCBI Gene Model | MGI Sequence Detail 261079 C57BL/6J ±  kb
    transcript NM_008846 RefSeq | MGI Sequence Detail 2588 C57BL/6  
    polypeptide P70181 UniProt | EBI | MGI Sequence Detail 539 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000012745 phosphatidylinositol 4-phosphate 5-kinase type-1 beta
      (term hierarchy)
    • EC
      2.7.1.68
    • InterPro Domains
      IPR023610 Phosphatidylinositol-4/5-phosphate 5/4-kinase
      IPR002498 Phosphatidylinositol-4-phosphate 4/5-kinase, core
      IPR027483 Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
      IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 26
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36510, MGI:2147609
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:35632 Ishihara H, et al., Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996 Sep 27;271(39):23611-4
    • Latest
      J:337007 Yang YS, et al., FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells. Stem Cells. 2023 Apr 25;41(4):354-367
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory