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Ndufs6 Gene Detail
Summary
  • Symbol
    Ndufs6
  • Name
    NADH:ubiquinone oxidoreductase core subunit S6
  • Synonyms
    IP13
  • Feature Type
    protein coding gene
  • IDs
    MGI:107932
    NCBI Gene: 407785
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73467995-73476574 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 39.69 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    389 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107932
 protein coding gene Chr13:73467957-73476661 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020743
 protein coding gene Chr13:73750476-73761356 (-)
A/J MGP_AJ_G0020699
 protein coding gene Chr13:71136850-71145510 (-)
AKR/J MGP_AKRJ_G0020673
 protein coding gene Chr13:73369320-73377981 (-)
BALB/cJ MGP_BALBcJ_G0020696
 protein coding gene Chr13:71628409-71637075 (-)
C3H/HeJ MGP_C3HHeJ_G0020490
 protein coding gene Chr13:73054665-73063329 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021133
 protein coding gene Chr13:76212326-76220981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018700
 protein coding gene Chr13:67944821-67953512 (-)
CAST/EiJ MGP_CASTEiJ_G0020007
 protein coding gene Chr13:72128131-72136968 (-)
CBA/J MGP_CBAJ_G0020449
 protein coding gene Chr13:79072643-79081296 (-)
DBA/2J MGP_DBA2J_G0020574
 protein coding gene Chr13:70958034-70967177 (-)
FVB/NJ MGP_FVBNJ_G0020554
 protein coding gene Chr13:69982578-69991249 (-)
LP/J MGP_LPJ_G0020647
 protein coding gene Chr13:74013697-74022376 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020582
 protein coding gene Chr13:77514492-77523132 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021172
 protein coding gene Chr13:72679149-72687826 (-)
PWK/PhJ MGP_PWKPhJ_G0019761
 protein coding gene Chr13:69683710-69692590 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019584
 protein coding gene Chr13:69145185-69153308 (-)
WSB/EiJ MGP_WSBEiJ_G0020065
 protein coding gene Chr13:73230072-73238720 (-)



Homology
more
  • Human Ortholog
    NDUFS6, NADH:ubiquinone oxidoreductase subunit S6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFS6, NADH:ubiquinone oxidoreductase subunit S6
  • Synonyms
    CI-13kA, CI-13kD-A, CI13KDA, MC1DN9
  • Links
    NCBI Gene ID: 4726
    neXtProt AC: NX_O75380
    UniProt: O75380

  • Chr Location
    5p15.33; chr5:1801407-1816048 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ndufs6 mouse models; 2 with human NDUFS6 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorph allele display premature death asscoiated with rapid weight loss and cardiac failure. These mice have enlarged hearts with impaired function and mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    11
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    101
  • cDNA Data
    83
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 407785 NCBI Gene Model | MGI Sequence Detail 8580 C57BL/6J ±  kb
    transcript NR_187110 RefSeq | MGI Sequence Detail 624 C57BL/6  
    polypeptide P52503 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 1
      cDNA 83
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36512, MGI:3039560
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory