About   Help   FAQ
Mns1 Gene Detail
Summary
  • Symbol
    Mns1
  • Name
    meiosis-specific nuclear structural protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107933
    NCBI Gene: 17427
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:72345276-72366036 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    673 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107933
 protein coding gene Chr9:72345276-72369307 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035014
 protein coding gene Chr9:72600849-72624811 (+)
A/J MGP_AJ_G0034995
 protein coding gene Chr9:70072215-70096117 (+)
AKR/J MGP_AKRJ_G0034924
 protein coding gene Chr9:71741117-71764960 (+)
BALB/cJ MGP_BALBcJ_G0034987
 protein coding gene Chr9:69779623-69803862 (+)
C3H/HeJ MGP_C3HHeJ_G0034696
 protein coding gene Chr9:72244199-72268112 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035506
 protein coding gene Chr9:74500647-74524585 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032417
 protein coding gene Chr9:69559609-69585596 (+)
CAST/EiJ MGP_CASTEiJ_G0034018
 protein coding gene Chr9:72553344-72579680 (+)
CBA/J MGP_CBAJ_G0034669
 protein coding gene Chr9:77100234-77127457 (+)
DBA/2J MGP_DBA2J_G0034828
 protein coding gene Chr9:69790633-69814505 (+)
FVB/NJ MGP_FVBNJ_G0034770
 protein coding gene Chr9:69102213-69128000 (+)
LP/J MGP_LPJ_G0034909
 protein coding gene Chr9:72804913-72828698 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034811
 protein coding gene Chr9:78174659-78199348 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035528
 protein coding gene Chr9:71886034-71909921 (+)
PWK/PhJ MGP_PWKPhJ_G0033722
 protein coding gene Chr9:70047379-70073279 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033555
 protein coding gene Chr9:72190887-72214192 (+)
WSB/EiJ MGP_WSBEiJ_G0034130
 protein coding gene Chr9:71815712-71840761 (+)



Homology
more
  • Human Ortholog
    MNS1, meiosis specific nuclear structural 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MNS1, meiosis specific nuclear structural 1
  • Synonyms
    HTX9, SPATA40
  • Links
    NCBI Gene ID: 55329
    neXtProt AC: NX_Q8NEH6
    UniProt: Q8NEH6

  • Chr Location
    15q21.3; chr15:56421544-56465137 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MNS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display partial lethality, male infertility, sperm flagellum abnormalities, immotile sperm, randomized left-right patterning, hydroencephaly, and motile cilia abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    47
  • cDNA Data
    42
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17427 NCBI Gene Model | MGI Sequence Detail 20761 C57BL/6J ±  kb
    transcript NM_001410430 RefSeq | MGI Sequence Detail 3112 C57BL/6  
    polypeptide Q61884 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 42
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36513, MGI:2143316
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 8
    • Earliest
      J:19855 Furukawa K, et al., cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res. 1994 Mar;2(2):99-113
    • Latest
      J:353048 Lu H, et al., Localisation and function of key axonemal microtubule inner proteins and dynein docking complex members reveal extensive diversity among vertebrate motile cilia. Development. 2024 Jul 15;151(14):dev202737
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory