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Mdm4 Gene Detail
Summary
  • Symbol
    Mdm4
  • Name
    transformed mouse 3T3 cell double minute 4
  • Synonyms
    4933417N07Rik, Mdmx
  • Feature Type
    protein coding gene
  • IDs
    MGI:107934
    NCBI Gene: 17248
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:132913843-132958325 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.75 cM, cytoband G-G
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1188 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107934
 protein coding gene Chr1:132887222-132958325 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016478
 protein coding gene Chr1:136465554-136540845 (-)
A/J MGP_AJ_G0016461
 protein coding gene Chr1:131406294-131481381 (-)
AKR/J MGP_AKRJ_G0016426
 protein coding gene Chr1:135269628-135346004 (-)
BALB/cJ MGP_BALBcJ_G0016421
 protein coding gene Chr1:131741347-131815536 (-)
C3H/HeJ MGP_C3HHeJ_G0016247
 protein coding gene Chr1:135417743-135490738 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016882
 protein coding gene Chr1:141517984-141615698 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014593
 protein coding gene Chr1:124591757-124637530 (-)
CAST/EiJ MGP_CASTEiJ_G0015827
 protein coding gene Chr1:134430845-134507770 (-)
CBA/J MGP_CBAJ_G0016219
 protein coding gene Chr1:146351916-146435734 (-)
DBA/2J MGP_DBA2J_G0016326
 protein coding gene Chr1:130373623-130442007 (-)
FVB/NJ MGP_FVBNJ_G0016325
 protein coding gene Chr1:129019230-129092432 (-)
LP/J MGP_LPJ_G0016397
 protein coding gene Chr1:137781505-137861491 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016350
 protein coding gene Chr1:152137579-152216013 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016918
 protein coding gene Chr1:135032008-135105473 (-)
PWK/PhJ MGP_PWKPhJ_G0015613
 protein coding gene Chr1:129367865-129447787 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015400
 protein coding gene Chr1:133982360-134059430 (-)
WSB/EiJ MGP_WSBEiJ_G0015889
 protein coding gene Chr1:135029174-135104388 (-)



Homology
more
  • Human Ortholog
    MDM4, MDM4 regulator of p53
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MDM4, MDM4 regulator of p53
  • Synonyms
    BMFS6, HDMX, MDMX, MRP1
  • Links
    NCBI Gene ID: 4194
    neXtProt AC: NX_O15151
    UniProt: O15151

  • Chr Location
    1q32.1; chr1:204516379-204558120 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mdm4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 9 alleles in 11 genetic backgrounds
    59 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality, decreased cellular proliferation, and abnormal nervous system development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    18
  • cDNA Data
    21
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17248 NCBI Gene Model | MGI Sequence Detail 44483 C57BL/6J ±  kb
    transcript NM_008575 RefSeq | MGI Sequence Detail 7298 ZRU/MplStud  
    polypeptide O35618 UniProt | EBI | MGI Sequence Detail 489 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 23
      Primer pair 2
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36514, MGI:1921697, MGI:2138095, MGI:2138388, MGI:2138425, MGI:2138465, MGI:2138710
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 11
      Phenotypes 76
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:339368 Yao F, et al., Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis. Cell Death Dis. 2023 Aug 23;14(8):543
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory