Slc8a3 MGI Mouse Gene Detail - MGI:107976 - solute carrier family 8 (sodium/calcium exchanger), member 3

Symbol

Slc8a3
Name

solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms

Ncx3

Feature Type

protein coding gene
IDs

MGI:107976
NCBI Gene: 110893
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:81244689-81379954 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 37.44 cM
Mapping Data

2 experiments

SNPs within 2kb

3053 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107976	protein coding gene	Chr12:81244686-81380506 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019898	protein coding gene	Chr12:81645275-81784747 (-)
A/J	MGP_AJ_G0019856	protein coding gene	Chr12:78648964-78786001 (-)
AKR/J	MGP_AKRJ_G0019831	protein coding gene	Chr12:80805358-80951042 (-)
BALB/cJ	MGP_BALBcJ_G0019835	protein coding gene	Chr12:78894653-79032020 (-)
C3H/HeJ	MGP_C3HHeJ_G0019641	protein coding gene	Chr12:81269655-81410438 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020287	protein coding gene	Chr12:84028201-84170038 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017906	protein coding gene	Chr12:75639692-75773397 (-)
CAST/EiJ	MGP_CASTEiJ_G0019191	protein coding gene	Chr12:76142607-76284308 (-)
CBA/J	MGP_CBAJ_G0019612	protein coding gene	Chr12:87290846-87434265 (-)
DBA/2J	MGP_DBA2J_G0019727	protein coding gene	Chr12:78253054-78387864 (-)
FVB/NJ	MGP_FVBNJ_G0019713	protein coding gene	Chr12:77078187-77213026 (-)
LP/J	MGP_LPJ_G0019799	protein coding gene	Chr12:81547316-81690471 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019752	protein coding gene	Chr12:90282920-90423125 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020322	protein coding gene	Chr12:80333242-80467241 (-)
PWK/PhJ	MGP_PWKPhJ_G0018957	protein coding gene	Chr12:72659807-72794184 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018751	protein coding gene	Chr12:74852609-75002236 (-)
WSB/EiJ	MGP_WSBEiJ_G0019244	protein coding gene	Chr12:80975118-81119768 (-)

Human Ortholog

SLC8A3, solute carrier family 8 member A3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC8A3, solute carrier family 8 member A3
Synonyms

NCX3
Links

HGNC:11070

NCBI Gene ID: 6547

neXtProt AC: NX_P57103

UniProt: P57103
Chr Location

14q24.2; chr14:70044215-70189480 (-) GRCh38

MGI Vertebrate Homology

Slc8a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC8A3
Gene Tree

Slc8a3

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

1 involving Slc8a3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display a normal phenotype.

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All GO Annotations

63
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

49
cDNA Data

19
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SLC8A3

Xenbase slc8a3

ZFIN slc8a3

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All Sequences

67
RefSeq

17
UniProt

8
CCDS

CCDS36485.1, CCDS49103.1

Ensembl

ENSMUSG00000079055 (Evidence)
NCBI Gene

110893

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079055	Ensembl Gene Model \| MGI Sequence Detail	135266	C57BL/6J	± kb
transcript	ENSMUST00000182208	Ensembl \| MGI Sequence Detail	3433	Not Applicable
polypeptide	ENSMUSP00000138735	Ensembl \| MGI Sequence Detail	928	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000015209 sodium/calcium exchanger 3

(term hierarchy)
PDB

2LT9
InterPro Domains

IPR051171 Calcium/Cation Antiporter

IPR038081 CalX-like domain superfamily

IPR003644 Na-Ca exchanger/integrin-beta4

IPR044880 NCX, central ion-binding domain superfamily

IPR032452 Sodium/calcium exchanger domain, C-terminal extension

IPR004837 Sodium/calcium exchanger membrane region

IPR004836 Sodium/calcium exchanger protein
GlyGen

S4R2P9 2 sites

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All nucleic 24

Genomic 2

cDNA 20

Primer pair 2

Microarray probesets 4

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MGD-MRK-36556, MGI:2145052

Summaries

All 64

Developmental Gene Expression 11

Gene Ontology 13

Phenotypes 19
Earliest

J:35796 Nicoll DA, et al., Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. J Biol Chem. 1996 Oct 4;271(40):24914-21
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc8a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116918	Chr12:81380297-81380326 (-)	-358 bp
Tssr116917	Chr12:81379903-81379994 (-)	5 bp
Tssr116916	Chr12:81333884-81333885 (-)	46,069 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24