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Klc1 Gene Detail
Summary
  • Symbol
    Klc1
  • Name
    kinesin light chain 1
  • Synonyms
    Kns2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107978
    NCBI Gene: 16593
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111725283-111774278 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.13 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1595 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107978
 protein coding gene Chr12:111724869-111774278 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020141
 protein coding gene Chr12:114169826-114226653 (+)
A/J MGP_AJ_G0020097
 protein coding gene Chr12:109784977-109836135 (+)
AKR/J MGP_AKRJ_G0020072
 protein coding gene Chr12:112931957-112984409 (+)
BALB/cJ MGP_BALBcJ_G0020082
 protein coding gene Chr12:110206517-110255518 (+)
C3H/HeJ MGP_C3HHeJ_G0019884
 protein coding gene Chr12:113429940-113482746 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020527
 protein coding gene Chr12:117720158-117774674 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018140
 protein coding gene Chr12:106219842-106268944 (+)
CAST/EiJ MGP_CASTEiJ_G0019425
 protein coding gene Chr12:108273077-108335669 (+)
CBA/J MGP_CBAJ_G0019851
 protein coding gene Chr12:122210669-122269839 (+)
DBA/2J MGP_DBA2J_G0019968
 protein coding gene Chr12:109260576-109311521 (+)
FVB/NJ MGP_FVBNJ_G0019953
 protein coding gene Chr12:108070050-108120088 (+)
LP/J MGP_LPJ_G0020043
 protein coding gene Chr12:114002618-114055400 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019991
 protein coding gene Chr12:125322550-125377197 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020556
 protein coding gene Chr12:112455635-112506779 (+)
PWK/PhJ MGP_PWKPhJ_G0019186
 protein coding gene Chr12:103908197-103958761 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018989
 protein coding gene Chr12:106616024-106669316 (+)
WSB/EiJ MGP_WSBEiJ_G0019484
 protein coding gene Chr12:113358581-113412979 (+)



Homology
more
  • Human Ortholog
    KLC1, kinesin light chain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLC1, kinesin light chain 1
  • Synonyms
    KLC, KNS2, KNS2A
  • Links
    NCBI Gene ID: 3831
    neXtProt AC: NX_Q07866
    UniProt: Q07866

  • Chr Location
    14q32.33; chr14:103561896-103714249 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KLC1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are significantly smaller than normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    911
  • Tissues
    49
  • cDNA Data
    176
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021288 Ensembl Gene Model | MGI Sequence Detail 48996 C57BL/6J ±  kb
    transcript ENSMUST00000239017 Ensembl | MGI Sequence Detail 4089 Not Applicable  
    polypeptide ENSMUSP00000159193 Ensembl | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      cDNA 176

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36558, MGI:2144913
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 17
      Phenotypes 25
    • Earliest
      J:37953 Lan Y, et al., The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mamm Genome. 1997;8(11):875-6
    • Latest
      J:317683 Chassefeyre R, et al., Endosomal sorting drives the formation of axonal prion protein endoggresomes. Sci Adv. 2021 Dec 24;7(52):eabg3693
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory