Polr1b MGI Mouse Gene Detail - MGI:108014 - polymerase (RNA) I polypeptide B

Symbol

Polr1b
Name

polymerase (RNA) I polypeptide B
Synonyms

128kDa, D630020H17Rik, RPA116, RPA2, Rpo1-2

Feature Type

protein coding gene
IDs

MGI:108014
NCBI Gene: 20017
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:128942915-128968514 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.68 cM, cytoband F3
Mapping Data

2 experiments

SNPs within 2kb

861 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108014	protein coding gene	Chr2:128942891-128969980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026483	protein coding gene	Chr2:132475407-132502327 (+)
A/J	MGP_AJ_G0026447	protein coding gene	Chr2:127107293-127133142 (+)
AKR/J	MGP_AKRJ_G0026422	protein coding gene	Chr2:130716265-130742651 (+)
BALB/cJ	MGP_BALBcJ_G0026459	protein coding gene	Chr2:127371967-127397449 (+)
C3H/HeJ	MGP_C3HHeJ_G0026202	protein coding gene	Chr2:131224289-131253748 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026904	protein coding gene	Chr2:136618499-136648111 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024281	protein coding gene	Chr2:121933177-121957209 (+)
CAST/EiJ	MGP_CASTEiJ_G0025663	protein coding gene	Chr2:131484572-131512158 (+)
CBA/J	MGP_CBAJ_G0026182	protein coding gene	Chr2:141668697-141697790 (+)
DBA/2J	MGP_DBA2J_G0026316	protein coding gene	Chr2:126496641-126522736 (+)
FVB/NJ	MGP_FVBNJ_G0026280	protein coding gene	Chr2:125146895-125172862 (+)
LP/J	MGP_LPJ_G0026421	protein coding gene	Chr2:132713991-132743543 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026300	protein coding gene	Chr2:145581284-145610811 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026959	protein coding gene	Chr2:130750958-130779026 (+)
PWK/PhJ	MGP_PWKPhJ_G0025399	protein coding gene	Chr2:126073498-126099713 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025201	protein coding gene	Chr2:129861101-129888818 (+)
WSB/EiJ	MGP_WSBEiJ_G0025737	protein coding gene	Chr2:131671868-131697693 (+)

Human Ortholog

POLR1B, RNA polymerase I subunit B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLR1B, RNA polymerase I subunit B
Synonyms

A135, RPA135, RPA2, Rpo1-2, TCS4
Links

HGNC:20454

NCBI Gene ID: 84172

neXtProt AC: NX_Q9H9Y6

UniProt: Q9H9Y6
Chr Location

2q14.1; chr2:112541915-112579818 (+) GRCh38

MGI Vertebrate Homology

Polr1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLR1B
Gene Tree

Polr1b

Diseases

1 with human POLR1B associations

				Human Disease	Mouse Models
				Treacher Collins syndrome 4 IDs Treacher Collins syndrome 4 DOID:0080792 OMIM:618939

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

16
Radiation induced

1
Genomic Mutations

2 involving Polr1b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit embryonic lethality prior to implantation.

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All GO Annotations

44
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

116
cDNA Data

93
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polr1b

ZFIN polr1b

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All Sequences

46
RefSeq

5
UniProt

3
CCDS

CCDS16720.1

Ensembl

ENSMUSG00000027395 (Evidence)
NCBI Gene

20017

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027395	Ensembl Gene Model \| MGI Sequence Detail	25600	C57BL/6J	± kb
transcript	ENSMUST00000103205	Ensembl \| MGI Sequence Detail	3998	Not Applicable
polypeptide	ENSMUSP00000099494	Ensembl \| MGI Sequence Detail	1135	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012983 DNA-directed RNA polymerase I subunit RPA2

(term hierarchy)
EC

2.7.7.6
InterPro Domains

IPR009674 DNA-directed RNA polymerase I subunit RPA2, domain 4

IPR015712 DNA-directed RNA polymerase, subunit 2

IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain

IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily

IPR007121 RNA polymerase, beta subunit, conserved site

IPR007644 RNA polymerase, beta subunit, protrusion

IPR007642 RNA polymerase Rpb2, domain 2

IPR037034 RNA polymerase Rpb2, domain 2 superfamily

IPR007645 RNA polymerase Rpb2, domain 3

IPR007641 RNA polymerase Rpb2, domain 7

IPR014724 RNA polymerase Rpb2, OB-fold

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All nucleic 94

cDNA 93

Primer pair 1

Microarray probesets 3

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MGD-MRK-37048, MGI:2443763

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 15

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Polr1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20096	Chr2:128942902-128942909 (+)	-9 bp
Tssr20097	Chr2:128942920-128942986 (+)	38 bp
Tssr20098	Chr2:128942994-128943003 (+)	84 bp
Tssr20099	Chr2:128964804-128964806 (+)	21,890 bp
Tssr20100	Chr2:128964984-128964989 (+)	22,072 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24