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Nkx3-2 Gene Detail
Summary
  • Symbol
    Nkx3-2
  • Name
    NK3 homeobox 2
  • Synonyms
    Bapx1, Nkx-3.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108015
    NCBI Gene: 12020
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:41918826-41921563 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 22.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108015
 protein coding gene Chr5:41918826-41921844 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029518
 protein coding gene Chr5:40342974-40346000 (-)
A/J MGP_AJ_G0029484
 protein coding gene Chr5:38994407-38997425 (-)
AKR/J MGP_AKRJ_G0029434
 protein coding gene Chr5:40383841-40386859 (-)
BALB/cJ MGP_BALBcJ_G0029495
 protein coding gene Chr5:39431060-39434078 (-)
C3H/HeJ MGP_C3HHeJ_G0029218
 protein coding gene Chr5:40379169-40382187 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029949
 protein coding gene Chr5:42376580-42379598 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027187
 protein coding gene Chr5:36379174-36382201 (-)
CAST/EiJ MGP_CASTEiJ_G0028626
 protein coding gene Chr5:39461969-39492639 (-)
CBA/J MGP_CBAJ_G0029185
 protein coding gene Chr5:43431639-43434657 (-)
DBA/2J MGP_DBA2J_G0029332
 protein coding gene Chr5:39062728-39065746 (-)
FVB/NJ MGP_FVBNJ_G0029291
 protein coding gene Chr5:38504765-38507783 (-)
LP/J MGP_LPJ_G0029418
 protein coding gene Chr5:40785129-40788155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029321
 protein coding gene Chr5:44269765-44272783 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029982
 protein coding gene Chr5:39871375-39874401 (-)
PWK/PhJ MGP_PWKPhJ_G0028350
 protein coding gene Chr5:38236837-38239875 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028184
 protein coding gene Chr5:39380007-39383043 (-)
WSB/EiJ MGP_WSBEiJ_G0028707
 protein coding gene Chr5:39936092-39939118 (-)



Homology
more
  • Human Ortholog
    NKX3-2, NK3 homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX3-2, NK3 homeobox 2
  • Synonyms
    BAPX1, NKX3.2, NKX3B, SMMD
  • Links
    NCBI Gene ID: 579
    neXtProt AC: NX_P78367
    UniProt: P78367

  • Chr Location
    4p15.33; chr4:13540830-13547744 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 7 alleles in 5 genetic backgrounds
    31 phenotypes from multigenic genotypes
    5 images
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are perinatal lethal, lack a spleen, and display skeletal dysplasia of the vertebral column and cranium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1093
  • Tissues
    232
  • cDNA Data
    14
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12020 NCBI Gene Model | MGI Sequence Detail 2738 C57BL/6J ±  kb
    transcript NM_007524 RefSeq | MGI Sequence Detail 1437 Not Specified  
    polypeptide P97503 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 3
      cDNA 15
      Primer pair 8
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37050
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 51
      Diseases 2
      Gene Ontology 11
      Phenotypes 60
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:357389 Schonblum A, et al., Beneficial islet inflammation in health depends on pericytic TLR/MyD88 signaling. J Clin Invest. 2024 Jun 17;134(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory