Epha6 MGI Mouse Gene Detail - MGI:108034

Symbol

Epha6
Name

Eph receptor A6
Synonyms

Ehk2, Hek12, m-ehk2

Feature Type

protein coding gene
IDs

MGI:108034
NCBI Gene: 13840
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:59473846-60425894 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 34.83 cM
Mapping Data

3 experiments

SNPs within 2kb

28124 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108034	protein coding gene	Chr16:59473424-60431196 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022933	protein coding gene	Chr16:58948921-59905272 (-)
A/J	MGP_AJ_G0022901	protein coding gene	Chr16:56452026-57389815 (-)
AKR/J	MGP_AKRJ_G0022871	protein coding gene	Chr16:58186643-59173676 (-)
BALB/cJ	MGP_BALBcJ_G0022903	protein coding gene	Chr16:56587416-57541459 (-)
C3H/HeJ	MGP_C3HHeJ_G0022665	protein coding gene	Chr16:58411351-59428232 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023351	protein coding gene	Chr16:60586717-61640612 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020854	protein coding gene	Chr16:55888239-56770140 (-)
CAST/EiJ	MGP_CASTEiJ_G0022189	protein coding gene	Chr16:58695867-59698355 (-)
CBA/J	MGP_CBAJ_G0022636	protein coding gene	Chr16:63025107-64134051 (-)
DBA/2J	MGP_DBA2J_G0022768	protein coding gene	Chr16:56148516-57090723 (-)
FVB/NJ	MGP_FVBNJ_G0022742	protein coding gene	Chr16:55862663-56799117 (-)
LP/J	MGP_LPJ_G0022837	protein coding gene	Chr16:58750611-59746701 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022761	protein coding gene	Chr16:63398266-64674004 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023367	protein coding gene	Chr16:58292623-59270835 (-)
PWK/PhJ	MGP_PWKPhJ_G0021931	protein coding gene	Chr16:56374894-57333155 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021761	protein coding gene	Chr16:58020667-59023884 (-)
WSB/EiJ	MGP_WSBEiJ_G0022235	protein coding gene	Chr16:58323545-59320228 (-)

Human Ortholog

EPHA6, EPH receptor A6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPHA6, EPH receptor A6
Synonyms

EHK-2, EHK2, EK12, EPA6, HEK12, PRO57066
Links

HGNC:19296

NCBI Gene ID: 285220

neXtProt AC: NX_Q9UF33

UniProt: Q9UF33
Chr Location

3q11.2; chr3:96814581-97761532 (+) GRCh38

MGI Vertebrate Homology

Epha6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EPHA6
Protein SuperFamily

TyrPK_ephrin_receptor
Gene Tree

Epha6

less

Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display discrete learning and memory deficits.

less

All GO Annotations

41
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

909
Tissues

88
cDNA Data

11
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase epha6

ZFIN epha6

less

All Sequences

38
RefSeq

6
UniProt

2
CCDS

CCDS28260.2

Ensembl

ENSMUSG00000055540 (Evidence)
NCBI Gene

13840

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055540	Ensembl Gene Model \| MGI Sequence Detail	952049	C57BL/6J	± kb
transcript	ENSMUST00000068860	Ensembl \| MGI Sequence Detail	3930	Not Applicable
polypeptide	ENSMUSP00000066734	Ensembl \| MGI Sequence Detail	1130	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000007126 ephrin type-A receptor 6

(term hierarchy)
PDB

5ZRY
EC

2.7.10.1
InterPro Domains

IPR042746 EPH-A6 , SAM domain

IPR001090 Ephrin receptor ligand binding domain

IPR027936 Ephrin receptor, transmembrane domain

IPR016257 Ephrin receptor type-A /type-B

IPR050449 Ephrin receptor tyrosine kinases

IPR034280 Ephrin type-A receptor 6, ligand binding domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR008979 Galactose-binding-like domain superfamily

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR013783 Immunoglobulin-like fold

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
GlyGen

Q62413 3 sites

less

All nucleic 22

cDNA 13

Primer pair 6

Other 3

Microarray probesets 3

less

MGD-MRK-37070

Summaries

All 80

Developmental Gene Expression 39

Gene Ontology 8

Phenotypes 11
Earliest

J:36316 Lee AM, et al., Cloning of m-ehk2 from the murine inner ear, an eph family receptor tyrosine kinase expressed in the developing and adult cochlea. DNA Cell Biol. 1996 Oct;15(10):817-25
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Epha6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141660	Chr16:60425974-60426006 (-)	-96 bp
Tssr141659	Chr16:60425954-60425972 (-)	-69 bp
Tssr141658	Chr16:60425908-60425922 (-)	-21 bp
Tssr141657	Chr16:60425634-60425654 (-)	250 bp
Tssr141656	Chr16:60425606-60425617 (-)	282 bp
Tssr141655	Chr16:60425589-60425592 (-)	303 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24