About   Help   FAQ
Traf3 Gene Detail
Summary
  • Symbol
    Traf3
  • Name
    TNF receptor-associated factor 3
  • Synonyms
    CAP-1, CD40bp, CRAF1, LAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108041
    NCBI Gene: 22031
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111132804-111233587 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.94 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2642 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108041
 protein coding gene Chr12:111132799-111233589 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020128
 protein coding gene Chr12:113532508-113638840 (+)
A/J MGP_AJ_G0020084
 protein coding gene Chr12:109178225-109279795 (+)
AKR/J MGP_AKRJ_G0020059
 protein coding gene Chr12:112305831-112408876 (+)
BALB/cJ MGP_BALBcJ_G0020069
 protein coding gene Chr12:109592864-109695095 (+)
C3H/HeJ MGP_C3HHeJ_G0019871
 protein coding gene Chr12:112777316-112913663 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020514
 protein coding gene Chr12:117058869-117168178 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018127
 protein coding gene Chr12:105620631-105722993 (+)
CAST/EiJ MGP_CASTEiJ_G0019412
 protein coding gene Chr12:107656593-107757590 (+)
CBA/J MGP_CBAJ_G0019838
 protein coding gene Chr12:121555426-121654343 (+)
DBA/2J MGP_DBA2J_G0019955
 protein coding gene Chr12:108662653-108762673 (+)
FVB/NJ MGP_FVBNJ_G0019940
 protein coding gene Chr12:107453765-107555234 (+)
LP/J MGP_LPJ_G0020030
 protein coding gene Chr12:113337344-113439283 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019978
 protein coding gene Chr12:124671719-124776495 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020543
 protein coding gene Chr12:111803375-111912523 (+)
PWK/PhJ MGP_PWKPhJ_G0019173
 protein coding gene Chr12:103292887-103394173 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018976
 protein coding gene Chr12:105971727-106076878 (+)
WSB/EiJ MGP_WSBEiJ_G0019471
 protein coding gene Chr12:112738742-112843078 (+)



Homology
more
  • Human Ortholog
    TRAF3, TNF receptor associated factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAF3, TNF receptor associated factor 3
  • Synonyms
    CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, RNF118
  • Links
    NCBI Gene ID: 7187
    neXtProt AC: NX_Q13114
    UniProt: Q13114

  • Chr Location
    14q32.32; chr14:102777449-102911500 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRAF3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 5 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in progressive runting, hypoglycemia, and depletion of peripheral white blood cells, leading to death by 10 days of age. Immune responses to T-dependent antigen are impaired in lethally irradiated mice reconstituted with mutant cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    49
  • cDNA Data
    125
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021277 Ensembl Gene Model | MGI Sequence Detail 100784 C57BL/6J ±  kb
    transcript ENSMUST00000021706 Ensembl | MGI Sequence Detail 7060 Not Applicable  
    polypeptide ENSMUSP00000021706 Ensembl | MGI Sequence Detail 567 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      Genomic 5
      cDNA 125
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36169, MGD-MRK-37077, MGI:2144858
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 7
      Gene Ontology 22
      Phenotypes 61
    • Earliest
      J:34086 Cheng G, et al., Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8
    • Latest
      J:346309 Zhu S, et al., The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion. Front Immunol. 2023;14:1167924
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory