Stx2 MGI Mouse Gene Detail - MGI:108059

Symbol

Stx2
Name

syntaxin 2
Synonyms

Epim, G1-536-1, repro34, Syn-2

Feature Type

protein coding gene
IDs

MGI:108059
NCBI Gene: 13852
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:129061621-129085638 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 67.99 cM
Mapping Data

4 experiments

SNPs within 2kb

843 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108059	protein coding gene	Chr5:129061621-129085664 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030122	protein coding gene	Chr5:133039649-133063640 (-)
A/J	MGP_AJ_G0030089	protein coding gene	Chr5:127447770-127471896 (-)
AKR/J	MGP_AKRJ_G0030023	protein coding gene	Chr5:131591964-131615967 (-)
BALB/cJ	MGP_BALBcJ_G0030099	protein coding gene	Chr5:128794569-128818558 (-)
C3H/HeJ	MGP_C3HHeJ_G0029816	protein coding gene	Chr5:132160272-132184281 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030552	protein coding gene	Chr5:138145421-138169420 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027777	protein coding gene	Chr5:121852444-121875006 (-)
CAST/EiJ	MGP_CASTEiJ_G0029225	protein coding gene	Chr5:131422187-131446469 (-)
CBA/J	MGP_CBAJ_G0029786	protein coding gene	Chr5:143512697-143536710 (-)
DBA/2J	MGP_DBA2J_G0029936	protein coding gene	Chr5:127433080-127457245 (-)
FVB/NJ	MGP_FVBNJ_G0029892	protein coding gene	Chr5:126497843-126521999 (-)
LP/J	MGP_LPJ_G0030025	protein coding gene	Chr5:133551131-133575135 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029923	protein coding gene	Chr5:146903412-146927975 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030593	protein coding gene	Chr5:131270211-131294362 (-)
PWK/PhJ	MGP_PWKPhJ_G0028939	protein coding gene	Chr5:126336404-126361126 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028776	protein coding gene	Chr5:128837146-128861104 (-)
WSB/EiJ	MGP_WSBEiJ_G0029299	protein coding gene	Chr5:131922461-131947509 (-)

Human Ortholog

STX2, syntaxin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STX2, syntaxin 2
Synonyms

EPIM, EPM, STX2A, STX2B, STX2C
Links

HGNC:3403

NCBI Gene ID: 2054

neXtProt AC: NX_P32856

UniProt: P32856
Chr Location

12q24.33; chr12:130789600-130839254 (-) GRCh38

MGI Vertebrate Homology

Stx2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: STX2
Gene Tree

Stx2

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Phenotype Summary

28 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Stx2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display male infertility associated with abnormal testicular development and impaired spermatogenesis, increased intestinal growth due to enhanced crypt cell proliferation and crypt fission, and decreased susceptibility to induced colitis.

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All GO Annotations

42
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

846
Tissues

73
cDNA Data

49
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA STX2

Xenbase stx2

ZFIN stx2a

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All Sequences

65
RefSeq

15
UniProt

6
CCDS

CCDS19692.1, CCDS71672.1

Ensembl

ENSMUSG00000029428 (Evidence)
NCBI Gene

13852

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029428	Ensembl Gene Model \| MGI Sequence Detail	24018	C57BL/6J	± kb
transcript	ENSMUST00000031378	Ensembl \| MGI Sequence Detail	2939	Not Applicable
polypeptide	ENSMUSP00000031378	Ensembl \| MGI Sequence Detail	289	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015794 syntaxin-2

(term hierarchy)
InterPro Domains

IPR010989 SNARE

IPR045242 Syntaxin

IPR028671 Syntaxin-2, SNARE motif

IPR006012 Syntaxin/epimorphin, conserved site

IPR006011 Syntaxin, N-terminal domain

IPR000727 Target SNARE coiled-coil homology domain

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All nucleic 50

cDNA 49

Primer pair 1

Microarray probesets 3

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MGD-MRK-37095, MGI:2141213, MGI:3692873

Summaries

All 68

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 28
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53481	Chr5:129085610-129085660 (-)	3 bp
Tssr53480	Chr5:129085558-129085601 (-)	58 bp
Tssr53479	Chr5:129084587-129084590 (-)	1,049 bp
Tssr53478	Chr5:129079772-129079801 (-)	5,851 bp
Tssr53477	Chr5:129066985-129066999 (-)	18,646 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24