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Siah1b Gene Detail
Summary
  • Symbol
    Siah1b
  • Name
    siah E3 ubiquitin protein ligase 1B
  • Synonyms
    Sinh1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:108063
    NCBI Gene: 20438
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:162853701-162859489 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.11 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108063
 protein coding gene ChrX:162853699-162859489 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036250
 protein coding gene ChrX:162144213-162149992 (-)
A/J MGP_AJ_G0036220
 protein coding gene ChrX:161313280-161323411 (-)
AKR/J MGP_AKRJ_G0036148
 protein coding gene ChrX:166504068-166509847 (-)
BALB/cJ MGP_BALBcJ_G0036213
 protein coding gene ChrX:159315981-159321760 (-)
C3H/HeJ MGP_C3HHeJ_G0035920
 protein coding gene ChrX:162494383-162500162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036736
 protein coding gene ChrX:166899050-166904837 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031346
 protein coding gene Chr8:78280089-78284417 (-)
CAST/EiJ MGP_CASTEiJ_G0035208
 protein coding gene ChrX:141468490-141473871 (-)
CBA/J MGP_CBAJ_G0035894
 protein coding gene ChrX:171725873-171731652 (-)
DBA/2J MGP_DBA2J_G0036060
 protein coding gene ChrX:160209229-160215655 (-)
FVB/NJ MGP_FVBNJ_G0035992
 protein coding gene ChrX:159341748-159347444 (-)
LP/J MGP_LPJ_G0036145
 protein coding gene ChrX:163283038-163288817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036024
 protein coding gene ChrX:180412066-180422143 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034424
 protein coding gene Chr8:86743911-86747810 (-)
PWK/PhJ MGP_PWKPhJ_G0034906
 protein coding gene ChrX:138253938-138261254 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034727
 protein coding gene ChrX:141972816-141977910 (-)
WSB/EiJ MGP_WSBEiJ_G0035343
 protein coding gene ChrX:159600900-159606070 (-)



Homology
more
  • Human Ortholog
    SIAH1, siah E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIAH1, siah E3 ubiquitin protein ligase 1
  • Synonyms
    BURHAS, SIAH1A
  • Links
    NCBI Gene ID: 6477
    neXtProt AC: NX_Q8IUQ4
    UniProt: Q8IUQ4

  • Chr Location
    16q12.1; chr16:48356364-48448402 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Primary mouse embryonic fibroblasts hemizygous for a targeted allele show no apparent alterations in Trp53-mediated responses or mitotic progression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    93
  • cDNA Data
    7
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040749 Ensembl Gene Model | MGI Sequence Detail 5789 C57BL/6J ±  kb
transcript ENSMUST00000037928 Ensembl | MGI Sequence Detail 1783 Not Applicable  
polypeptide ENSMUSP00000043215 Ensembl | MGI Sequence Detail 282 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 8
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14420, MGD-MRK-37100, MGI:2147835
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:12699 Della NG, et al., Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). Development. 1993 Apr;117(4):1333-43
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory