Cxcl1 Gene Detail

Summary

• Symbol
  Cxcl1
• Name
  C-X-C motif chemokine ligand 1
• Synonyms
  Fsp, Gro1, KC, KC/GRO-alpha, Mgsa, N51, Scyb1

• Feature Type
  protein coding gene
• IDs
  MGI:108068
  NCBI Gene: 14825
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr5:91039100-91040974 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 44.78 cM, cytoband E-F
• Mapping Data
  15 experiments

Strain
Comparison

• SNPs within 2kb
  165 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  11

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108068	protein coding gene	Chr5:91039100-91040980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029731	protein coding gene	Chr5:91983100-91984968 (+)
A/J	MGP_AJ_G0029697	protein coding gene	Chr5:88356388-88358262 (+)
AKR/J	MGP_AKRJ_G0029643	protein coding gene	Chr5:91216449-91218323 (+)
BALB/cJ	MGP_BALBcJ_G0029707	protein coding gene	Chr5:89257869-89259743 (+)
C3H/HeJ	MGP_C3HHeJ_G0029430	protein coding gene	Chr5:91641775-91643649 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030161	protein coding gene	Chr5:95644814-95646688 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027397	protein coding gene	Chr5:84045886-84047719 (+)
CAST/EiJ	MGP_CASTEiJ_G0028840	protein coding gene	Chr5:91002167-91004041 (+)
CBA/J	MGP_CBAJ_G0029400	protein coding gene	Chr5:98941641-98943515 (+)
DBA/2J	MGP_DBA2J_G0029544	protein coding gene	Chr5:88431001-88432875 (+)
FVB/NJ	MGP_FVBNJ_G0029503	protein coding gene	Chr5:87278729-87280603 (+)
LP/J	MGP_LPJ_G0029632	protein coding gene	Chr5:92363337-92365205 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029532	protein coding gene	Chr5:103911598-103913472 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030195	protein coding gene	Chr5:90767517-90769385 (+)
PWK/PhJ	MGP_PWKPhJ_G0028559	protein coding gene	Chr5:87480527-87482359 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028394	protein coding gene	Chr5:90164026-90165859 (+)
WSB/EiJ	MGP_WSBEiJ_G0028919	protein coding gene	Chr5:91212779-91214647 (+)

Homology

• Human Ortholog
  CXCL1, C-X-C motif chemokine ligand 1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CXCL1, C-X-C motif chemokine ligand 1
  
• Synonyms
  FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
• Links
  HGNC:4602

  NCBI Gene ID: 2919

  neXtProt AC: NX_P09341

  UniProt: P09341

  
  
• Chr Location
  4q13.3; chr4:73869393-73871308 (+)  GRCh38

---

• Human Ortholog
  CXCL2, C-X-C motif chemokine ligand 2
  
• Synonyms
  CINC-2a, GRO2, GROb, MGSA-b, MIP2, MIP-2a, MIP2A, SCYB2
• Links
  HGNC:4603

  NCBI Gene ID: 2920

  neXtProt AC: NX_P19875

  UniProt: P19875

  
  
• Chr Location
  4q13.3; chr4:74097040-74099196 (-)  GRCh38

---

• MGI Vertebrate Homology
  Cxcl1 stringent orthology
  2 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CXCL1, CXCL2
• Gene Tree
  Cxcl1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  2 phenotypes from multigenic genotypes
  30 phenotype references
  

• All Mutations and Alleles
  14
• Chemically induced (other)
  2
• Endonuclease-mediated
  8
• Radiation induced
  1
• Spontaneous
  1
• Targeted
  1
• Transgenic
  1
• Genomic Mutations
  4 involving Cxcl1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  12 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Targeted mutations in this gene when combine with targeted mutation of Ldlr decreases susceptibility to atherosclerotic lesions.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  19
• GO References
  13

Expression

• Assay Results
  796
• Tissues
  58
• cDNA Data
  21
• Literature Summary
  39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  39
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS39143.1

• Ensembl
  ENSMUSG00000029380 (Evidence)
• NCBI Gene
  14825

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000029380	Ensembl Gene Model | MGI Sequence Detail	1875	C57BL/6J
transcript	ENSMUST00000031327	Ensembl | MGI Sequence Detail	953	Not Applicable
polypeptide	ENSMUSP00000031327	Ensembl | MGI Sequence Detail	96	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000006063 growth-regulated alpha protein
  (term hierarchy)
• InterPro Domains
  IPR039809 Chemokine beta/gamma/delta
  IPR001811 Chemokine interleukin-8-like domain
  IPR036048 Chemokine interleukin-8-like superfamily
  IPR001089 CXC chemokine
  IPR018048 CXC chemokine, conserved site
  IPR033899 CXC Chemokine domain

Molecular
Reagents

• All nucleic 35

  cDNA 22

  Primer pair 12

  Other 1

  
  

  Microarray probesets 6

Other
Accession IDs

MGD-MRK-12226, MGD-MRK-37105, MGD-MRK-9878

References

• Summaries
  All 202

  Developmental Gene Expression 39

  Gene Ontology 13

  Phenotypes 30
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:352714 Yang J, et al., ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death. J Med Genet. 2024 Jul 19;61(8):750-758

TSS for Cxcl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47215	Chr5:91039093-91039109 (+)	1 bp
Tssr47216	Chr5:91039690-91039701 (+)	596 bp