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Hdac1 Gene Detail
Summary
  • Symbol
    Hdac1
  • Name
    histone deacetylase 1
  • Synonyms
    HD1, MommeD5, RPD3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108086
    NCBI Gene: 433759
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129409897-129436506 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    299 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108086
 protein coding gene Chr4:129409897-129436516 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028827
 protein coding gene Chr4:131439431-131474828 (-)
A/J MGP_AJ_G0028786
 protein coding gene Chr4:126194872-126220328 (-)
AKR/J MGP_AKRJ_G0028739
 protein coding gene Chr4:129700388-129740421 (-)
BALB/cJ MGP_BALBcJ_G0028809
 protein coding gene Chr4:126791443-126824190 (-)
C3H/HeJ MGP_C3HHeJ_G0028523
 protein coding gene Chr4:129765282-129790468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029251
 protein coding gene Chr4:136386965-136418540 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026523
 protein coding gene Chr4:119326652-119350771 (-)
CAST/EiJ MGP_CASTEiJ_G0027955
 protein coding gene Chr4:127945696-127975149 (-)
CBA/J MGP_CBAJ_G0028489
 protein coding gene Chr4:139761553-139796240 (-)
DBA/2J MGP_DBA2J_G0028638
 protein coding gene Chr4:126627162-126654335 (-)
FVB/NJ MGP_FVBNJ_G0028605
 protein coding gene Chr4:125387760-125412159 (-)
LP/J MGP_LPJ_G0028739
 protein coding gene Chr4:131717666-131750815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028631
 protein coding gene Chr4:144597061-144623611 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029289
 protein coding gene Chr4:130081050-130108406 (-)
PWK/PhJ MGP_PWKPhJ_G0027677
 protein coding gene Chr4:123223636-123256914 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027503
 protein coding gene Chr4:125944673-125970038 (-)
WSB/EiJ MGP_WSBEiJ_G0028036
 protein coding gene Chr4:130202058-130230178 (-)



Homology
more
  • Human Ortholog
    HDAC1, histone deacetylase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC1, histone deacetylase 1
  • Synonyms
    GON-10, HD1, KDAC1, RPD3, RPD3L1
  • Links
    NCBI Gene ID: 3065
    neXtProt AC: NX_Q13547
    UniProt: Q13547

  • Chr Location
    1p35.2-p35.1; chr1:32292083-32333635 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 9 alleles in 10 genetic backgrounds
    60 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos between E9.5 and E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    206
  • GO References
    95
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1131
  • Tissues
    188
  • cDNA Data
    8
  • Literature Summary
    67
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028800 Ensembl Gene Model | MGI Sequence Detail 26610 C57BL/6J ±  kb
    transcript ENSMUST00000102597 Ensembl | MGI Sequence Detail 2038 Not Applicable  
    polypeptide ENSMUSP00000099657 Ensembl | MGI Sequence Detail 482 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 8
      Primer pair 14
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37123, MGI:3586542
    References
    more
    • Summaries
      All 343
      Developmental Gene Expression 67
      Gene Ontology 95
      Phenotypes 92
    • Earliest
      J:36570 Yang WM, et al., Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50
    • Latest
      J:353625 Zhu Y, et al., HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural progenitor transition during brain development. iScience. 2024 Sep 20;27(9):110600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory