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Ei24 Gene Detail
Summary
  • Symbol
    Ei24
  • Name
    etoposide induced 2.4 mRNA
  • Synonyms
    PIG8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108090
    NCBI Gene: 13663
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:36690449-36708630 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108090
 protein coding gene Chr9:36690449-36708689 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034556
 protein coding gene Chr9:34696628-34715119 (-)
A/J MGP_AJ_G0034535
 protein coding gene Chr9:33798116-33816766 (-)
AKR/J MGP_AKRJ_G0034462
 protein coding gene Chr9:34542669-34562828 (-)
BALB/cJ MGP_BALBcJ_G0034526
 protein coding gene Chr9:33640883-33659362 (-)
C3H/HeJ MGP_C3HHeJ_G0034239
 protein coding gene Chr9:34955008-34975297 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035048
 protein coding gene Chr9:35833544-35851752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031974
 protein coding gene Chr9:32930240-32949203 (-)
CAST/EiJ MGP_CASTEiJ_G0033560
 protein coding gene Chr9:34653676-34671617 (-)
CBA/J MGP_CBAJ_G0034212
 protein coding gene Chr9:37065596-37083817 (-)
DBA/2J MGP_DBA2J_G0034370
 protein coding gene Chr9:33850568-33868799 (-)
FVB/NJ MGP_FVBNJ_G0034311
 protein coding gene Chr9:33109111-33127532 (-)
LP/J MGP_LPJ_G0034455
 protein coding gene Chr9:34935490-34955227 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034357
 protein coding gene Chr9:38718292-38736592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035067
 protein coding gene Chr9:34473484-34492596 (-)
PWK/PhJ MGP_PWKPhJ_G0033266
 protein coding gene Chr9:33751856-33770646 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033100
 protein coding gene Chr9:34687485-34707473 (-)
WSB/EiJ MGP_WSBEiJ_G0033676
 protein coding gene Chr9:34279185-34297581 (-)



Homology
more
  • Human Ortholog
    EI24, EI24 autophagy associated transmembrane protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EI24, EI24 autophagy associated transmembrane protein
  • Synonyms
    EPG4, PIG8, TP53I8
  • Links
    NCBI Gene ID: 9538
    neXtProt AC: NX_O14681
    UniProt: O14681

  • Chr Location
    11q24.2; chr11:125569280-125584684 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 2 alleles in 3 genetic backgrounds
    8 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele do not survive to the neonatal stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    65
  • cDNA Data
    127
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13663 NCBI Gene Model | MGI Sequence Detail 18182 C57BL/6J ±  kb
    transcript NM_001433198 RefSeq | MGI Sequence Detail 2419 C57BL/6  
    polypeptide Q61070 UniProt | EBI | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      cDNA 129
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37127, MGI:2142953, MGI:2142976
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:36240 Lehar SM, et al., Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene. 1996 Mar 21;12(6):1181-7
    • Latest
      J:279693 Nam TW, et al., Effect of EI24 expression on the tumorigenesis of Apc(Min/+) colorectal cancer mouse model. Biochem Biophys Res Commun. 2019 Jul 5;514(4):1087-1092
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory