Dvl3 MGI Mouse Gene Detail - MGI:108100 - dishevelled segment polarity protein 3

Symbol

Dvl3
Name

dishevelled segment polarity protein 3
Synonyms

b2b2866Clo

Feature Type

protein coding gene
IDs

MGI:108100
NCBI Gene: 13544
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr16:20335732-20352760 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 12.46 cM
Mapping Data

3 experiments

SNPs within 2kb

398 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108100	protein coding gene	Chr16:20335694-20352763 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022643	protein coding gene	Chr16:17855076-17870351 (+)
A/J	MGP_AJ_G0022605	protein coding gene	Chr16:16992952-17008182 (+)
AKR/J	MGP_AKRJ_G0022580	protein coding gene	Chr16:17643467-17658437 (+)
BALB/cJ	MGP_BALBcJ_G0022609	protein coding gene	Chr16:17153805-17168789 (+)
C3H/HeJ	MGP_C3HHeJ_G0022374	protein coding gene	Chr16:17799026-17814225 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023060	protein coding gene	Chr16:18200051-18215454 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020577	protein coding gene	Chr16:17683764-17699001 (+)
CAST/EiJ	MGP_CASTEiJ_G0021904	protein coding gene	Chr16:17777697-17792834 (+)
CBA/J	MGP_CBAJ_G0022346	protein coding gene	Chr16:18942782-18959682 (+)
DBA/2J	MGP_DBA2J_G0022478	protein coding gene	Chr16:16922520-16937837 (+)
FVB/NJ	MGP_FVBNJ_G0022453	protein coding gene	Chr16:16952928-16968288 (+)
LP/J	MGP_LPJ_G0022545	protein coding gene	Chr16:17582651-17599566 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022473	protein coding gene	Chr16:18632643-18647705 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023071	protein coding gene	Chr16:17597793-17615028 (+)
PWK/PhJ	MGP_PWKPhJ_G0021645	protein coding gene	Chr16:17183770-17199371 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021474	protein coding gene	Chr16:17404357-17419614 (+)
WSB/EiJ	MGP_WSBEiJ_G0021948	protein coding gene	Chr16:17591561-17606904 (+)

Human Ortholog

DVL3, dishevelled segment polarity protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DVL3, dishevelled segment polarity protein 3
Synonyms

DRS3
Links

HGNC:3087

NCBI Gene ID: 1857

neXtProt AC: NX_Q92997

UniProt: Q92997
Chr Location

3q27.1; chr3:184155377-184173614 (+) GRCh38

MGI Vertebrate Homology

Dvl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DVL3
Gene Tree

Dvl3

Diseases

2 with human DVL3 associations

				Human Disease	Mouse Models
				autosomal dominant Robinow syndrome 3 IDs autosomal dominant Robinow syndrome 3 DOID:0060767 OMIM:616894 ORDO:3107 ORDO:97360
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 2 alleles in 3 genetic backgrounds
30 phenotypes from multigenic genotypes
16 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit postnatal lethality associated with respiratory distress, persistent truncus arteriosis, and double outlet right ventricle.

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All GO Annotations

53
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1005
Tissues

191
cDNA Data

11
Literature Summary

30

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DVL2

Xenbase dvl3

ZFIN dvl3a

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All Sequences

50
RefSeq

13
UniProt

4
CCDS

CCDS37287.1, CCDS84210.1

Ensembl

ENSMUSG00000003233 (Evidence)
NCBI Gene

13544

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003233	Ensembl Gene Model \| MGI Sequence Detail	17029	C57BL/6J	± kb
transcript	ENSMUST00000171572	Ensembl \| MGI Sequence Detail	3983	Not Applicable
polypeptide	ENSMUSP00000130925	Ensembl \| MGI Sequence Detail	718	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006768 segment polarity protein dishevelled DVL-3

(term hierarchy)
InterPro Domains

IPR000591 DEP domain

IPR008342 Dishevelled-3

IPR024580 Dishevelled C-terminal

IPR008339 Dishevelled family

IPR003351 Dishevelled protein domain

IPR015506 Dishevelled-related protein

IPR001158 DIX domain

IPR038207 DIX domain superfamily

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR029071 Ubiquitin-like domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 23

Genomic 2

cDNA 11

Primer pair 10

Microarray probesets 3

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MGD-MRK-37137, MGI:5618435

Summaries

All 81

Developmental Gene Expression 30

Gene Ontology 18

Phenotypes 13
Earliest

J:36588 Tsang M, et al., Isolation and characterization of mouse dishevelled-3. Dev Dyn. 1996 Nov;207(3):253-62
Latest

J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)

TSS for Dvl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137435	Chr16:20335635-20335646 (+)	-91 bp
Tssr137436	Chr16:20335712-20335749 (+)	-1 bp
Tssr137437	Chr16:20335750-20335822 (+)	54 bp
Tssr137438	Chr16:20335826-20335880 (+)	121 bp
Tssr137439	Chr16:20350344-20350356 (+)	14,618 bp
Tssr137440	Chr16:20350605-20350620 (+)	14,881 bp
Tssr137441	Chr16:20351229-20351259 (+)	15,512 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24