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Dhx9 Gene Detail
Summary
  • Symbol
    Dhx9
  • Name
    DExH-box helicase 9
  • Synonyms
    Ddx9, leukophysin, NDH II, NDHII, nuclear DNA helicase II, RHA, RNA helicase
  • Feature Type
    protein coding gene
  • IDs
    MGI:108177
    NCBI Gene: 13211
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:153331504-153363406 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.37 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    700 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108177
 protein coding gene Chr1:153331504-153363464 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016597
 protein coding gene Chr1:158279406-158312420 (-)
A/J MGP_AJ_G0016579
 protein coding gene Chr1:151901694-151933596 (-)
AKR/J MGP_AKRJ_G0016544
 protein coding gene Chr1:156605696-156637598 (-)
BALB/cJ MGP_BALBcJ_G0016539
 protein coding gene Chr1:152451992-152483895 (-)
C3H/HeJ MGP_C3HHeJ_G0016364
 protein coding gene Chr1:156703624-156735526 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017000
 protein coding gene Chr1:163754437-163787534 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014709
 protein coding gene Chr1:144193948-144230026 (-)
CAST/EiJ MGP_CASTEiJ_G0015943
 protein coding gene Chr1:156218512-156258981 (-)
CBA/J MGP_CBAJ_G0016338
 protein coding gene Chr1:169513486-169545397 (-)
DBA/2J MGP_DBA2J_G0016444
 protein coding gene Chr1:150924285-150955975 (-)
FVB/NJ MGP_FVBNJ_G0016442
 protein coding gene Chr1:149388588-149420554 (-)
LP/J MGP_LPJ_G0016515
 protein coding gene Chr1:159404611-159436546 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016468
 protein coding gene Chr1:177144504-177177874 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017036
 protein coding gene Chr1:156377168-156409103 (-)
PWK/PhJ MGP_PWKPhJ_G0015729
 protein coding gene Chr1:149960840-149993449 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015516
 protein coding gene Chr1:155175423-155207358 (-)
WSB/EiJ MGP_WSBEiJ_G0016006
 protein coding gene Chr1:156452225-156485153 (-)



Homology
more
  • Human Ortholog
    DHX9, DExH-box helicase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX9, DExH-box helicase 9
  • Synonyms
    DDX9, LKP, MRD75, NDH2, NDHII, RHA
  • Links
    NCBI Gene ID: 1660
    neXtProt AC: NX_Q08211
    UniProt: Q08211

  • Chr Location
    1q25.3; chr1:182839347-182887982 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes die in embryonic stages with massive apoptotic cell death in embryonic ectodermal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    181
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1062
  • Tissues
    102
  • cDNA Data
    70
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042699 Ensembl Gene Model | MGI Sequence Detail 31903 C57BL/6J ±  kb
    transcript ENSMUST00000042141 Ensembl | MGI Sequence Detail 4616 Not Applicable  
    polypeptide ENSMUSP00000038135 Ensembl | MGI Sequence Detail 1384 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000006474 ATP-dependent RNA helicase A
      (term hierarchy)
    • PDB
      1UIL, 1WHQ, 2RS6, 2RS7
    • EC
      3.6.4.13
    • InterPro Domains
      IPR011709 DEAD-box helicase, OB fold
      IPR011545 DEAD/DEAH box helicase domain
      IPR044447 DHX9, DEXH-box helicase domain
      IPR044445 DHX9, first double-stranded RNA binding domain
      IPR044446 DHX9, second double-stranded RNA binding domain
      IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
      IPR014720 Double-stranded RNA-binding domain
      IPR007502 Helicase-associated domain
      IPR048333 Helicase associated domain (HA2), winged-helix domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      O70133 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 3
      cDNA 70
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37216, MGI:2138215
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 20
    • Earliest
      J:45144 Miazek A, et al., Identification of a T cell lineage-specific RNA/DNA helicase and its cell surface expression during intrathymic education of alphabeta and gammadelta T cells. Eur J Immunol. 1997 Dec;27(12):3269-82
    • Latest
      J:347283 Ren X, et al., DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nat Commun. 2024 Apr 9;15(1):3080
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory