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Pcbp2 Gene Detail
Summary
  • Symbol
    Pcbp2
  • Name
    poly(rC) binding protein 2
  • Synonyms
    alphaCP-2, Hnrpx
  • Feature Type
    protein coding gene
  • IDs
    MGI:108202
    NCBI Gene: 18521
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102378974-102408496 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.61 cM, cytoband F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    440 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108202
 protein coding gene Chr15:102378974-102408503 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022415
 protein coding gene Chr15:104657586-104689789 (+)
A/J MGP_AJ_G0022377
 protein coding gene Chr15:100533060-100564596 (+)
AKR/J MGP_AKRJ_G0022352
 protein coding gene Chr15:103580168-103609747 (+)
BALB/cJ MGP_BALBcJ_G0022381
 protein coding gene Chr15:100590721-100619884 (+)
C3H/HeJ MGP_C3HHeJ_G0022148
 protein coding gene Chr15:103657562-103687763 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022830
 protein coding gene Chr15:108549102-108587107 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020353
 protein coding gene Chr15:96312888-96341615 (+)
CAST/EiJ MGP_CASTEiJ_G0021674
 protein coding gene Chr15:104533440-104567017 (+)
CBA/J MGP_CBAJ_G0022117
 protein coding gene Chr15:112363797-112397698 (+)
DBA/2J MGP_DBA2J_G0022248
 protein coding gene Chr15:99819373-99848241 (+)
FVB/NJ MGP_FVBNJ_G0022224
 protein coding gene Chr15:98881034-98910294 (+)
LP/J MGP_LPJ_G0022317
 protein coding gene Chr15:104808679-104839636 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022246
 protein coding gene Chr15:115919013-115951416 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022842
 protein coding gene Chr15:103618455-103651942 (+)
PWK/PhJ MGP_PWKPhJ_G0021414
 protein coding gene Chr15:99979651-100013306 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021246
 protein coding gene Chr15:103462330-103494399 (+)
WSB/EiJ MGP_WSBEiJ_G0021724
 protein coding gene Chr15:104248186-104278578 (+)



Homology
more
  • Human Ortholog
    PCBP2, poly(rC) binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCBP2, poly(rC) binding protein 2
  • Synonyms
    hnRNP-E2, HNRNPE2, HNRPE2
  • Links
    NCBI Gene ID: 5094
    neXtProt AC: NX_Q15366
    UniProt: Q15366

  • Chr Location
    12q13.13; chr12:53452102-53481162 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit decreased body weight, impaired erythroblast maturation and lowered mean platelet counts. Mice homozygous for this allele die between E12.5 and E15.5 with hemorrhage and edema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    22
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056851 Ensembl Gene Model | MGI Sequence Detail 29523 C57BL/6J ±  kb
    transcript ENSMUST00000077037 Ensembl | MGI Sequence Detail 2952 Not Applicable  
    polypeptide ENSMUSP00000076294 Ensembl | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 19
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10809, MGD-MRK-37241, MGI:2146212, MGI:96165
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 38
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:332496 Martinelli M, et al., The poly(C)-binding protein Pcbp2 is essential for CD4(+) T cell activation and proliferation. iScience. 2023 Jan 20;26(1):105860
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory