Ripk1 MGI Mouse Gene Detail - MGI:108212 - receptor (TNFRSF)-interacting serine-threonine kinase 1

Symbol

Ripk1
Name

receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms

Rinp, Rip1

Feature Type

protein coding gene
IDs

MGI:108212
NCBI Gene: 19766
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:34186346-34221130 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 14.01 cM
Mapping Data

3 experiments

SNPs within 2kb

1012 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108212	protein coding gene	Chr13:34181072-34221130 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020445	protein coding gene	Chr13:32105301-32139798 (+)
A/J	MGP_AJ_G0020400	protein coding gene	Chr13:31163449-31196230 (+)
AKR/J	MGP_AKRJ_G0020377	protein coding gene	Chr13:31900130-31934212 (+)
BALB/cJ	MGP_BALBcJ_G0020395	protein coding gene	Chr13:31239938-31272594 (+)
C3H/HeJ	MGP_C3HHeJ_G0020194	protein coding gene	Chr13:31830359-31864529 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020829	protein coding gene	Chr13:33175920-33213061 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018416	protein coding gene	Chr13:29479412-29513152 (+)
CAST/EiJ	MGP_CASTEiJ_G0019710	protein coding gene	Chr13:31487991-31521415 (+)
CBA/J	MGP_CBAJ_G0020154	protein coding gene	Chr13:34618008-34650856 (+)
DBA/2J	MGP_DBA2J_G0020276	protein coding gene	Chr13:30695303-30728198 (+)
FVB/NJ	MGP_FVBNJ_G0020256	protein coding gene	Chr13:30271780-30304427 (+)
LP/J	MGP_LPJ_G0020352	protein coding gene	Chr13:32334077-32366807 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020287	protein coding gene	Chr13:34839785-34872606 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020872	protein coding gene	Chr13:31561434-31594252 (+)
PWK/PhJ	MGP_PWKPhJ_G0019465	protein coding gene	Chr13:30811317-30844792 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019290	protein coding gene	Chr13:30212397-30247280 (+)
WSB/EiJ	MGP_WSBEiJ_G0019772	protein coding gene	Chr13:31917770-31951174 (+)

Human Ortholog

RIPK1, receptor interacting serine/threonine kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIPK1, receptor interacting serine/threonine kinase 1
Synonyms

AIEFL, IMD57, RIP, RIP-1, RIP1
Links

HGNC:10019

NCBI Gene ID: 8737

neXtProt AC: NX_Q13546

UniProt: Q13546
Chr Location

6p25.2; chr6:3063824-3115187 (+) GRCh38

MGI Vertebrate Homology

Ripk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RIPK1
Gene Tree

Ripk1

Diseases

1 with human RIPK1 associations

				Human Disease	Mouse Models
				immunodeficiency 57 IDs immunodeficiency 57 DOID:0111952 OMIM:618108 ORDO:529977

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotypes from multigenic genotypes
151 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Endonuclease-mediated

22
Gene trapped

2
Radiation induced

1
Targeted

13
Genomic Mutations

2 involving Ripk1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die within 1 and 3 days of birth displaying extensive apoptosis in both lymphoid and adipose tissue.

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All GO Annotations

176
GO References

52

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

884
Tissues

35
cDNA Data

15
Literature Summary

26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ripk1

ZFIN ripk1l

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All Sequences

52
RefSeq

10
UniProt

2
CCDS

CCDS26443.1

Ensembl

ENSMUSG00000021408 (Evidence)
NCBI Gene

19766

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021408	Ensembl Gene Model \| MGI Sequence Detail	34785	C57BL/6J	± kb
transcript	ENSMUST00000021844	Ensembl \| MGI Sequence Detail	3266	Not Applicable
polypeptide	ENSMUSP00000021844	Ensembl \| MGI Sequence Detail	656	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014022 receptor-interacting serine/threonine-protein kinase 1

(term hierarchy)
PDB

8IB0
EC

2.7.11.1
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR025735 RHIM domain

IPR037934 RIP1, Death domain

IPR050167 Serine/threonine-protein kinase

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
GlyGen

Q60855 1 site, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 6

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MGD-MRK-37251

Summaries

All 320

Developmental Gene Expression 26

Gene Ontology 52

Phenotypes 151
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:353859 Jetton D, et al., Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection. Cell Rep. 2024 Aug 27;43(8):114641

TSS for Ripk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119206	Chr13:34186358-34186406 (+)	36 bp
Tssr119207	Chr13:34186413-34186424 (+)	73 bp
Tssr119208	Chr13:34194650-34194658 (+)	8,308 bp
Tssr119209	Chr13:34205433-34205449 (+)	19,095 bp
Tssr119210	Chr13:34205631-34205638 (+)	19,289 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24