Pxn MGI Mouse Gene Detail - MGI:108295

Symbol

Pxn
Name

paxillin
Synonyms

Pax

Feature Type

protein coding gene
IDs

MGI:108295
NCBI Gene: 19303
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr5:115644735-115694046 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.10 cM
Mapping Data

1 experiment

SNPs within 2kb

1601 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108295	protein coding gene	Chr5:115630035-115694046 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029972	protein coding gene	Chr5:118403195-118454257 (+)
A/J	MGP_AJ_G0029936	protein coding gene	Chr5:113681275-113732428 (+)
AKR/J	MGP_AKRJ_G0029875	protein coding gene	Chr5:117321789-117376960 (+)
BALB/cJ	MGP_BALBcJ_G0029947	protein coding gene	Chr5:115077539-115127020 (+)
C3H/HeJ	MGP_C3HHeJ_G0029667	protein coding gene	Chr5:117840757-117894031 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030402	protein coding gene	Chr5:122955784-123007836 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027629	protein coding gene	Chr5:108454753-108505658 (+)
CAST/EiJ	MGP_CASTEiJ_G0029076	protein coding gene	Chr5:116778257-116837141 (+)
CBA/J	MGP_CBAJ_G0029635	protein coding gene	Chr5:127684023-127737024 (+)
DBA/2J	MGP_DBA2J_G0029785	protein coding gene	Chr5:113770097-113820736 (+)
FVB/NJ	MGP_FVBNJ_G0029741	protein coding gene	Chr5:112587105-112638317 (+)
LP/J	MGP_LPJ_G0029873	protein coding gene	Chr5:118957474-119010324 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029772	protein coding gene	Chr5:131984872-132037476 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030443	protein coding gene	Chr5:116804701-116853965 (+)
PWK/PhJ	MGP_PWKPhJ_G0028789	protein coding gene	Chr5:112415049-112465755 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028627	protein coding gene	Chr5:114351387-114400945 (+)
WSB/EiJ	MGP_WSBEiJ_G0029151	protein coding gene	Chr5:117401909-117451415 (+)

Human Ortholog

PXN, paxillin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PXN, paxillin
Links

HGNC:9718

NCBI Gene ID: 5829

neXtProt AC: NX_P49023

UniProt: P49023
Chr Location

12q24.23; chr12:120210439-120265771 (-) GRCh38

MGI Vertebrate Homology

Pxn stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PXN
Protein SuperFamily

Leupaxin
Gene Tree

Pxn

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

31
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Pxn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice die at E9.5 with defects in the amnion, allantois, and headfold structures, as well as impaired growth, and abnormal heart and somite development; mutant fibroblasts show aberrant fibronectin-regulated focal adhesion dynamics, and disorganized membrane cytoskeletal structures.

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All GO Annotations

57
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

949
Tissues

96
cDNA Data

87
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pxn

ZFIN pxna, pxnb

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All Sequences

114
RefSeq

28
UniProt

8
CCDS

CCDS19593.1, CCDS39229.1

Ensembl

ENSMUSG00000029528 (Evidence)
NCBI Gene

19303

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029528	Ensembl Gene Model \| MGI Sequence Detail	49312	C57BL/6J	± kb
transcript	ENSMUST00000212819	Ensembl \| MGI Sequence Detail	3189	Not Applicable
polypeptide	ENSMUSP00000148843	Ensembl \| MGI Sequence Detail	1062	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000013512 paxillin

(term hierarchy)
PDB

5W93, 6JMU
InterPro Domains

IPR051352 Cell Adhesion and Viral Modulation Protein

IPR017305 Leupaxin/Paxillin/TGFB1I1

IPR047072 Paxillin, Lim domain 2

IPR001904 Paxillin, Lim domain 4

IPR047075 Paxillin/TGFB1I1, LIM domain 1

IPR001781 Zinc finger, LIM-type
GlyGen

Q8VI36 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 101

Genomic 8

cDNA 88

Primer pair 5

Microarray probesets 4

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MGD-MRK-37334, MGI:2141153, MGI:2141158

Summaries

All 160

Developmental Gene Expression 34

Gene Ontology 27

Phenotypes 26
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:343567 Hijazi N, et al., Paxillin regulates liver fibrosis via actin polymerization and ERK activation in hepatic stellate cells. J Cell Sci. 2023 Sep 15;136(18)

TSS for Pxn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48301	Chr5:115644727-115644812 (+)	35 bp
Tssr48302	Chr5:115657718-115657738 (+)	12,993 bp
Tssr48303	Chr5:115657743-115657805 (+)	13,039 bp
Tssr48304	Chr5:115680965-115680996 (+)	36,246 bp
Tssr48305	Chr5:115681003-115681015 (+)	36,274 bp
Tssr48306	Chr5:115681031-115681066 (+)	36,314 bp
Tssr48307	Chr5:115682141-115682159 (+)	37,415 bp
Tssr48308	Chr5:115682165-115682204 (+)	37,450 bp
Tssr48309	Chr5:115682278-115682313 (+)	37,561 bp
Tssr48310	Chr5:115682400-115682437 (+)	37,684 bp
Tssr48311	Chr5:115682457-115682483 (+)	37,735 bp
Tssr48312	Chr5:115683331-115683374 (+)	38,618 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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