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Btg2 Gene Detail
Summary
  • Symbol
    Btg2
  • Name
    BTG anti-proliferation factor 2
  • Synonyms
    APRO1, Pc3, TIS21
  • Feature Type
    protein coding gene
  • IDs
    MGI:108384
    NCBI Gene: 12227
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134002908-134006858 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.10 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108384
 protein coding gene Chr1:134002603-134006893 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016497
 protein coding gene Chr1:137719780-137723728 (-)
A/J MGP_AJ_G0016480
 protein coding gene Chr1:132540209-132544159 (-)
AKR/J MGP_AKRJ_G0016445
 protein coding gene Chr1:136496660-136500608 (-)
BALB/cJ MGP_BALBcJ_G0016440
 protein coding gene Chr1:132873381-132877330 (-)
C3H/HeJ MGP_C3HHeJ_G0016266
 protein coding gene Chr1:136588211-136592162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016901
 protein coding gene Chr1:142745774-142749724 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014612
 protein coding gene Chr1:125684480-125688470 (-)
CAST/EiJ MGP_CASTEiJ_G0015846
 protein coding gene Chr1:135640067-135644026 (-)
CBA/J MGP_CBAJ_G0016239
 protein coding gene Chr1:147660487-147664428 (-)
DBA/2J MGP_DBA2J_G0016345
 protein coding gene Chr1:131551729-131555677 (-)
FVB/NJ MGP_FVBNJ_G0016344
 protein coding gene Chr1:130178522-130182470 (-)
LP/J MGP_LPJ_G0016416
 protein coding gene Chr1:138991706-138995656 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016369
 protein coding gene Chr1:153385520-153389484 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016937
 protein coding gene Chr1:136214774-136218731 (-)
PWK/PhJ MGP_PWKPhJ_G0015632
 protein coding gene Chr1:130567805-130571866 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015419
 protein coding gene Chr1:135188283-135192247 (-)
WSB/EiJ MGP_WSBEiJ_G0015909
 protein coding gene Chr1:136244847-136248796 (-)



Homology
more
  • Human Ortholog
    BTG2, BTG anti-proliferation factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTG2, BTG anti-proliferation factor 2
  • Synonyms
    APRO1, PC3, TIS21
  • Links
    NCBI Gene ID: 7832
    neXtProt AC: NX_P78543
    UniProt: P78543

  • Chr Location
    1q32.1; chr1:203305491-203309602 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null Btg2tm1Wbh mice do not exhibit an overt phenotype. Homozygous null Btg2tm1Spo mice exhibit posterior homeotic transformations of the axial vertebrae.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1100
  • Tissues
    157
  • cDNA Data
    150
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020423 Ensembl Gene Model | MGI Sequence Detail 3951 C57BL/6J ±  kb
    transcript ENSMUST00000020692 Ensembl | MGI Sequence Detail 2743 Not Applicable  
    polypeptide ENSMUSP00000020692 Ensembl | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 154
      Genomic 1
      cDNA 150
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37424, MGI:2138132
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 51
      Gene Ontology 12
      Phenotypes 54
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:350486 Ceccarelli M, et al., Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells. Brain Pathol. 2024 Jun 30;:e13283
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory