Slc20a1 MGI Mouse Gene Detail - MGI:108392 - solute carrier family 20, member 1

Symbol

Slc20a1
Name

solute carrier family 20, member 1
Synonyms

Glvr-1, Glvr1, PiT-1

Feature Type

protein coding gene
IDs

MGI:108392
NCBI Gene: 20515
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:129040684-129053536 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.79 cM
Mapping Data

8 experiments

SNPs within 2kb

327 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108392	protein coding gene	Chr2:129038662-129053536 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026485	protein coding gene	Chr2:132578005-132590810 (+)
A/J	MGP_AJ_G0026449	protein coding gene	Chr2:127205219-127217971 (+)
AKR/J	MGP_AKRJ_G0026424	protein coding gene	Chr2:130818474-130831222 (+)
BALB/cJ	MGP_BALBcJ_G0026461	protein coding gene	Chr2:127471200-127484495 (+)
C3H/HeJ	MGP_C3HHeJ_G0026204	protein coding gene	Chr2:131333470-131346355 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026906	protein coding gene	Chr2:136727699-136741477 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024283	protein coding gene	Chr2:122028355-122041844 (+)
CAST/EiJ	MGP_CASTEiJ_G0025665	protein coding gene	Chr2:131584464-131597471 (+)
CBA/J	MGP_CBAJ_G0026184	protein coding gene	Chr2:141786177-141800834 (+)
DBA/2J	MGP_DBA2J_G0026318	protein coding gene	Chr2:126593993-126607046 (+)
FVB/NJ	MGP_FVBNJ_G0026282	protein coding gene	Chr2:125243759-125256727 (+)
LP/J	MGP_LPJ_G0026423	protein coding gene	Chr2:132819247-132834152 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026302	protein coding gene	Chr2:145684421-145698284 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026961	protein coding gene	Chr2:130853624-130866589 (+)
PWK/PhJ	MGP_PWKPhJ_G0025401	protein coding gene	Chr2:126179152-126192807 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025203	protein coding gene	Chr2:129973259-129989078 (+)
WSB/EiJ	MGP_WSBEiJ_G0025739	protein coding gene	Chr2:131775668-131789466 (+)

Human Ortholog

SLC20A1, solute carrier family 20 member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC20A1, solute carrier family 20 member 1
Synonyms

Glvr-1, GLVR1, PiT-1, PIT1
Links

HGNC:10946

NCBI Gene ID: 6574

neXtProt AC: NX_Q8WUM9

UniProt: Q8WUM9
Chr Location

2q14.1; chr2:112645939-112663825 (+) GRCh38

MGI Vertebrate Homology

Slc20a1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC20A1
Gene Tree

Slc20a1

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Phenotype Summary

43 phenotypes from 5 alleles in 6 genetic backgrounds
9 images
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

6
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Slc20a1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit mid-gestation lethality associated with abnormal vitelline vasculature, growth retardation, and anemia.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

999
Tissues

152
cDNA Data

14
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc20a1

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All Sequences

59
RefSeq

11
UniProt

3
CCDS

CCDS16722.1

Ensembl

ENSMUSG00000027397 (Evidence)
NCBI Gene

20515

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027397	Ensembl Gene Model \| MGI Sequence Detail	12853	C57BL/6J	± kb
transcript	ENSMUST00000028880	Ensembl \| MGI Sequence Detail	3316	Not Applicable
polypeptide	ENSMUSP00000028880	Ensembl \| MGI Sequence Detail	681	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014979 sodium-dependent phosphate transporter 1

(term hierarchy)
InterPro Domains

IPR001204 Phosphate transporter
GlyGen

Q61609 1 site, 1 N-linked glycan (1 site)

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All nucleic 28

Genomic 2

cDNA 19

Primer pair 6

Other 1

Microarray probesets 5

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MGD-MRK-10163, MGD-MRK-10164, MGD-MRK-37434, MGI:2139020

Summaries

All 69

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 22
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:344457 Ramos-Brossier M, et al., Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability. Cell Death Dis. 2024 Jan 9;15(1):20

TSS for Slc20a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20105	Chr2:129040677-129040689 (+)	-1 bp
Tssr20106	Chr2:129040713-129040731 (+)	38 bp
Tssr20107	Chr2:129047126-129047130 (+)	6,444 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24