Rgs8 MGI Mouse Gene Detail - MGI:108408 - regulator of G-protein signaling 8

Symbol

Rgs8
Name

regulator of G-protein signaling 8
Synonyms

6530413N01Rik

Feature Type

protein coding gene
IDs

MGI:108408
NCBI Gene: 67792
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:153528612-153573415 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.41 cM, cytoband G2
Mapping Data

3 experiments

SNPs within 2kb

1219 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108408	protein coding gene	Chr1:153528612-153576069 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016599	protein coding gene	Chr1:158496348-158544426 (+)
A/J	MGP_AJ_G0016581	protein coding gene	Chr1:152101538-152152729 (+)
AKR/J	MGP_AKRJ_G0016546	protein coding gene	Chr1:156815463-156862364 (+)
BALB/cJ	MGP_BALBcJ_G0016541	protein coding gene	Chr1:152652821-152700025 (+)
C3H/HeJ	MGP_C3HHeJ_G0016366	protein coding gene	Chr1:156911235-156962478 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017002	protein coding gene	Chr1:163971381-164019721 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014711	protein coding gene	Chr1:144390897-144438220 (+)
CAST/EiJ	MGP_CASTEiJ_G0015945	protein coding gene	Chr1:156429443-156481215 (+)
CBA/J	MGP_CBAJ_G0016340	protein coding gene	Chr1:169730636-169786834 (+)
DBA/2J	MGP_DBA2J_G0016446	protein coding gene	Chr1:151127003-151175955 (+)
FVB/NJ	MGP_FVBNJ_G0016444	protein coding gene	Chr1:149585536-149633071 (+)
LP/J	MGP_LPJ_G0016517	protein coding gene	Chr1:159611893-159666246 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016470	protein coding gene	Chr1:177360396-177412451 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017038	protein coding gene	Chr1:156588822-156640719 (+)
PWK/PhJ	MGP_PWKPhJ_G0015731	protein coding gene	Chr1:150165212-150214970 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015518	protein coding gene	Chr1:155383497-155438230 (+)
WSB/EiJ	MGP_WSBEiJ_G0016008	protein coding gene	Chr1:156671109-156722567 (+)

Human Ortholog

RGS8, regulator of G protein signaling 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS8, regulator of G protein signaling 8
Links

HGNC:16810

NCBI Gene ID: 85397

neXtProt AC: NX_P57771

UniProt: P57771
Chr Location

1q25.3; chr1:182641816-182752376 (-) GRCh38

MGI Vertebrate Homology

Rgs8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RGS8
Gene Tree

Rgs8

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

2
Targeted

1
Genomic Mutations

2 involving Rgs8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit normal fertility and Purkinje cell morphology.

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All GO Annotations

23
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

30
cDNA Data

77
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs8

ZFIN rgs8

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All Sequences

92
RefSeq

34
UniProt

7
CCDS

CCDS15375.1, CCDS83607.1

Ensembl

ENSMUSG00000042671 (Evidence)
NCBI Gene

67792

			Length	Strain/Species	Flank
genomic	67792	NCBI Gene Model \| MGI Sequence Detail	44804	C57BL/6J	± kb
transcript	NM_026380	RefSeq \| MGI Sequence Detail	5827	ZRU/MplStud
polypeptide	Q8BXT1	UniProt \| EBI \| MGI Sequence Detail	180	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013964 regulator of G-protein signaling 8

(term hierarchy)
InterPro Domains

IPR034949 Regulator of G-protein signalling 8, RGS domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR044926 RGS, subdomain 2

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All nucleic 78

cDNA 78

Microarray probesets 4

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MGD-MRK-37451, MGI:1915042

Summaries

All 46

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 8
Earliest

J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rgs8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9461	Chr1:153528676-153528677 (+)	65 bp
Tssr9462	Chr1:153528689-153528700 (+)	83 bp
Tssr9463	Chr1:153528852-153528922 (+)	275 bp
Tssr9464	Chr1:153541028-153541071 (+)	12,438 bp
Tssr9465	Chr1:153541236-153541250 (+)	12,631 bp
Tssr9466	Chr1:153541333-153541341 (+)	12,725 bp
Tssr9467	Chr1:153541373-153541399 (+)	12,774 bp
Tssr9468	Chr1:153541412-153541425 (+)	12,807 bp
Tssr9469	Chr1:153543249-153543258 (+)	14,642 bp
Tssr9470	Chr1:153543381-153543386 (+)	14,772 bp
Tssr9471	Chr1:153543416-153543422 (+)	14,807 bp
Tssr9472	Chr1:153571079-153571085 (+)	42,470 bp
Tssr9473	Chr1:153571112-153571120 (+)	42,504 bp
Tssr9474	Chr1:153571241-153571269 (+)	42,643 bp
Tssr9475	Chr1:153572229-153572248 (+)	43,627 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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