Ptpn18 MGI Mouse Gene Detail - MGI:108410 - protein tyrosine phosphatase, non-receptor type 18

Symbol

Ptpn18
Name

protein tyrosine phosphatase, non-receptor type 18
Synonyms

FLP1, HSCF, PTP-HSCF, Ptpk1, PTP-K1

Feature Type

protein coding gene
IDs

MGI:108410
NCBI Gene: 19253
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:34498843-34514814 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 13.25 cM
Mapping Data

4 experiments

SNPs within 2kb

570 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108410	protein coding gene	Chr1:34498827-34514814 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015909	protein coding gene	Chr1:32847094-32866294 (+)
A/J	MGP_AJ_G0015893	protein coding gene	Chr1:32062679-32079062 (+)
AKR/J	MGP_AKRJ_G0015849	protein coding gene	Chr1:32450248-32466031 (+)
BALB/cJ	MGP_BALBcJ_G0015847	protein coding gene	Chr1:31711520-31727659 (+)
C3H/HeJ	MGP_C3HHeJ_G0015681	protein coding gene	Chr1:32647965-32664658 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016300	protein coding gene	Chr1:34340196-34362142 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014022	protein coding gene	Chr1:29223386-29239456 (+)
CAST/EiJ	MGP_CASTEiJ_G0015261	protein coding gene	Chr1:32504321-32522528 (+)
CBA/J	MGP_CBAJ_G0015652	protein coding gene	Chr1:35295943-35313813 (+)
DBA/2J	MGP_DBA2J_G0015753	protein coding gene	Chr1:31386686-31402737 (+)
FVB/NJ	MGP_FVBNJ_G0015755	protein coding gene	Chr1:30937447-30955849 (+)
LP/J	MGP_LPJ_G0015823	protein coding gene	Chr1:33186056-33206630 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015775	protein coding gene	Chr1:37546176-37570110 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016347	protein coding gene	Chr1:32438000-32457322 (+)
PWK/PhJ	MGP_PWKPhJ_G0015044	protein coding gene	Chr1:31117220-31133500 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014827	protein coding gene	Chr1:32417110-32434019 (+)
WSB/EiJ	MGP_WSBEiJ_G0015323	protein coding gene	Chr1:32422797-32438666 (+)

Human Ortholog

PTPN18, protein tyrosine phosphatase non-receptor type 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN18, protein tyrosine phosphatase non-receptor type 18
Synonyms

BDP1, PTP-HSCF
Links

HGNC:9649

NCBI Gene ID: 26469

neXtProt AC: NX_Q99952

UniProt: Q99952
Chr Location

2q21.1; chr2:130356045-130375405 (+) GRCh38

MGI Vertebrate Homology

Ptpn18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTPN18
Gene Tree

Ptpn18

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Ptpn18
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

72
cDNA Data

16
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpn18

ZFIN ptpn18

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All Sequences

51
RefSeq

10
UniProt

3
CCDS

CCDS14867.1

Ensembl

ENSMUSG00000026126 (Evidence)
NCBI Gene

19253

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026126	Ensembl Gene Model \| MGI Sequence Detail	15972	C57BL/6J	± kb
transcript	ENSMUST00000027302	Ensembl \| MGI Sequence Detail	1559	Not Applicable
polypeptide	ENSMUSP00000027302	Ensembl \| MGI Sequence Detail	453	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013453 tyrosine-protein phosphatase non-receptor type 18

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR047170 Tyrosine-protein phosphatase non-receptor type 12/18/22

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 21

Genomic 1

cDNA 17

Primer pair 3

Microarray probesets 4

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MGD-MRK-37453

Summaries

All 40

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 10
Earliest

J:36011 Huang K, et al., Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Oncogene. 1996 Oct 3;13(7):1567-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ptpn18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35	Chr1:34498805-34498821 (+)	-30 bp
Tssr6219	Chr1:34498837-34498895 (+)	23 bp
Tssr6220	Chr1:34511795-34511838 (+)	12,974 bp
Tssr6221	Chr1:34511846-34511853 (+)	13,007 bp
Tssr6222	Chr1:34511862-34511873 (+)	13,025 bp
Tssr6223	Chr1:34512294-34512326 (+)	13,467 bp
Tssr6224	Chr1:34512344-34512377 (+)	13,518 bp
Tssr6225	Chr1:34512395-34512403 (+)	13,556 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24