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Nrtn Gene Detail
Summary
  • Symbol
    Nrtn
  • Name
    neurturin
  • Feature Type
    protein coding gene
  • IDs
    MGI:108417
    NCBI Gene: 18188
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57058325-57064530 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108417
 protein coding gene Chr17:57058323-57064548 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023937
 protein coding gene Chr17:58473496-58479451 (-)
A/J MGP_AJ_G0023895
 protein coding gene Chr17:56867705-56873930 (-)
AKR/J MGP_AKRJ_G0023864
 protein coding gene Chr17:57583791-57592486 (-)
BALB/cJ MGP_BALBcJ_G0023896
 protein coding gene Chr17:56686110-56692101 (-)
C3H/HeJ MGP_C3HHeJ_G0023660
 protein coding gene Chr17:58308407-58314621 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024342
 protein coding gene Chr17:60735954-60743569 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021788
 protein coding gene Chr17:53340767-53347142 (-)
CAST/EiJ MGP_CASTEiJ_G0023142
 protein coding gene Chr17:58582606-58588805 (-)
CBA/J MGP_CBAJ_G0023636
 protein coding gene Chr17:63120780-63126939 (-)
DBA/2J MGP_DBA2J_G0023764
 protein coding gene Chr17:55567152-55573353 (-)
FVB/NJ MGP_FVBNJ_G0023730
 protein coding gene Chr17:55122651-55128886 (-)
LP/J MGP_LPJ_G0023846
 protein coding gene Chr17:59158181-59164382 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023758
 protein coding gene Chr17:62592501-62599840 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024386
 protein coding gene Chr17:57941973-57947930 (-)
PWK/PhJ MGP_PWKPhJ_G0022888
 protein coding gene Chr17:54929220-54935594 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022699
 protein coding gene Chr17:54702573-54708766 (-)
WSB/EiJ MGP_WSBEiJ_G0023208
 protein coding gene Chr17:58554128-58564785 (-)



Homology
more
  • Human Ortholog
    NRTN, neurturin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRTN, neurturin
  • Synonyms
    NTN
  • Links
    NCBI Gene ID: 4902
    neXtProt AC: NX_Q99748
    UniProt: Q99748

  • Chr Location
    19p13.3; chr19:5805067-5828324 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NRTN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene have drooping, thickened eyelids which are a manifestation of abnormalities in the parasympathetic system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    147
  • cDNA Data
    21
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039481 Ensembl Gene Model | MGI Sequence Detail 6206 C57BL/6J ±  kb
    transcript ENSMUST00000044752 Ensembl | MGI Sequence Detail 1023 Not Applicable  
    polypeptide ENSMUSP00000046512 Ensembl | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 21
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37460
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 27
      Gene Ontology 11
      Phenotypes 27
    • Earliest
      J:40677 Kotzbauer PT, et al., Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature. 1996 Dec 5;384(6608):467-70
    • Latest
      J:325733 Gadomski S, et al., A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise. Cell Stem Cell. 2022 Apr 7;29(4):528-544.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory