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Kif1b Gene Detail
Summary
  • Symbol
    Kif1b
  • Name
    kinesin family member 1B
  • Synonyms
    A530096N05Rik, D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, mKIAA0591, N-3 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:108426
    NCBI Gene: 16561
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149260776-149392150 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 79.05 cM, cytoband E
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    880 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108426
 protein coding gene Chr4:149260776-149392762 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029137
 protein coding gene Chr4:153003834-153144490 (-)
A/J MGP_AJ_G0029102
 protein coding gene Chr4:146616570-146754379 (-)
AKR/J MGP_AKRJ_G0029050
 protein coding gene Chr4:150634461-150775276 (-)
BALB/cJ MGP_BALBcJ_G0029118
 protein coding gene Chr4:147127158-147258984 (-)
C3H/HeJ MGP_C3HHeJ_G0028839
 protein coding gene Chr4:151196523-151336280 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029567
 protein coding gene Chr4:158524661-158669863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026813
 protein coding gene Chr4:139043161-139171401 (-)
CAST/EiJ MGP_CASTEiJ_G0028252
 protein coding gene Chr4:148420645-148563452 (-)
CBA/J MGP_CBAJ_G0028801
 protein coding gene Chr4:163178230-163324151 (-)
DBA/2J MGP_DBA2J_G0028950
 protein coding gene Chr4:146736940-146868544 (-)
FVB/NJ MGP_FVBNJ_G0028914
 protein coding gene Chr4:145838933-145971772 (-)
LP/J MGP_LPJ_G0029040
 protein coding gene Chr4:152932582-153068157 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028941
 protein coding gene Chr4:166427734-166577422 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029599
 protein coding gene Chr4:151137059-151274618 (-)
PWK/PhJ MGP_PWKPhJ_G0027972
 protein coding gene Chr4:142734637-142869452 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027806
 protein coding gene Chr4:145367482-145510423 (-)
WSB/EiJ MGP_WSBEiJ_G0028332
 protein coding gene Chr4:151287330-151427761 (-)



Homology
more
  • Human Ortholog
    KIF1B, kinesin family member 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF1B, kinesin family member 1B
  • Synonyms
    CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1
  • Links
    NCBI Gene ID: 23095
    neXtProt AC: NX_O60333
    UniProt: O60333

  • Chr Location
    1p36.22; chr1:10210570-10381603 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kif1b mouse models; 5 with human KIF1B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1085
  • Tissues
    129
  • cDNA Data
    28
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063077 Ensembl Gene Model | MGI Sequence Detail 131375 C57BL/6J ±  kb
    transcript ENSMUST00000238956 Ensembl | MGI Sequence Detail 10434 Not Applicable  
    polypeptide ENSMUSP00000158941 Ensembl | MGI Sequence Detail 1883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 4
      cDNA 31
      Primer pair 5

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGD-MRK-35098, MGD-MRK-37469, MGI:106641, MGI:2140281, MGI:2140318, MGI:2442923
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 17
      Phenotypes 21
    • Earliest
      J:113711 Matthews RH, et al., Biphasic kinetic plots and specific analogs distinguishing and describing amino acid transport sites in S37 ascites tumor cells. Biochim Biophys Acta. 1975 Jun 25;394(2):182-92
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory