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Insl3 Gene Detail
Summary
  • Symbol
    Insl3
  • Name
    insulin-like 3
  • Synonyms
    Ley I-L, Rlf, Rlnl
  • Feature Type
    protein coding gene
  • IDs
    MGI:108427
    NCBI Gene: 16336
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:72141896-72143221 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108427
 protein coding gene Chr8:72141858-72143221 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033761
 protein coding gene Chr8:72103123-72104485 (+)
A/J MGP_AJ_G0033744
 protein coding gene Chr8:69165558-69166919 (+)
AKR/J MGP_AKRJ_G0033670
 protein coding gene Chr8:71214694-71216056 (+)
BALB/cJ MGP_BALBcJ_G0033740
 protein coding gene Chr8:69351588-69352950 (+)
C3H/HeJ MGP_C3HHeJ_G0033450
 protein coding gene Chr8:71787301-71788663 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034258
 protein coding gene Chr8:74846565-74847926 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031200
 protein coding gene Chr8:63800001-63801337 (+)
CAST/EiJ MGP_CASTEiJ_G0032775
 protein coding gene Chr8:71245300-71246662 (+)
CBA/J MGP_CBAJ_G0033428
 protein coding gene Chr8:77494908-77496270 (+)
DBA/2J MGP_DBA2J_G0033582
 protein coding gene Chr8:68891620-68892982 (+)
FVB/NJ MGP_FVBNJ_G0033524
 protein coding gene Chr8:67989106-67990468 (+)
LP/J MGP_LPJ_G0033669
 protein coding gene Chr8:72076777-72078139 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033571
 protein coding gene Chr8:80036458-80037819 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034275
 protein coding gene Chr8:71270105-71271467 (+)
PWK/PhJ MGP_PWKPhJ_G0032482
 protein coding gene Chr8:68181210-68182572 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032319
 protein coding gene Chr8:70217690-70218996 (+)
WSB/EiJ MGP_WSBEiJ_G0032891
 protein coding gene Chr8:71619473-71620835 (+)



Homology
more
  • Human Ortholog
    INSL3, insulin like 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INSL3, insulin like 3
  • Synonyms
    ley-I-L, RLF, RLNL
  • Links
    NCBI Gene ID: 3640
    neXtProt AC: NX_P51460
    UniProt: P51460

  • Chr Location
    19p13.11; chr19:17816512-17821574 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Insl3 mouse models; 1 with human INSL3 associations

Human Disease Mouse Models
      
IDs
 View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutations that inactivate the locus result in abnormal gubernaculae development and consequent bilateral cryptorchidism. Spermatogenesis is impaired and male mice are infertile. Female infertility due to disregulation of the oestrus cycle was observed in one mutant line.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    33
  • cDNA Data
    9
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16336 NCBI Gene Model | MGI Sequence Detail 1326 C57BL/6J ±  kb
    transcript NM_013564 RefSeq | MGI Sequence Detail 587 ZRU/MplStud  
    polypeptide O09107 UniProt | EBI | MGI Sequence Detail 122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 9
      Primer pair 4
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-37470, MGI:1194923
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 36
      Diseases 2
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:33724 Pusch W, et al., Molecular cloning and expression of the relaxin-like factor from the mouse testis. Endocrinology. 1996 Jul;137(7):3009-13
    • Latest
      J:334094 Gu X, et al., Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions. Nat Commun. 2023 Mar 15;14(1):1439
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory