Cpeb1 MGI Mouse Gene Detail - MGI:108442 - cytoplasmic polyadenylation element binding protein 1

Symbol

Cpeb1
Name

cytoplasmic polyadenylation element binding protein 1

Feature Type

protein coding gene
IDs

MGI:108442
NCBI Gene: 12877
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:80996774-81105207 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 45.71 cM
Mapping Data

2 experiments

SNPs within 2kb

2230 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108442	protein coding gene	Chr7:80996774-81105213 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032428	protein coding gene	Chr7:83403017-83514602 (-)
A/J	MGP_AJ_G0032407	protein coding gene	Chr7:81434319-81539811 (-)
AKR/J	MGP_AKRJ_G0032343	protein coding gene	Chr7:83241009-83346550 (-)
BALB/cJ	MGP_BALBcJ_G0032419	protein coding gene	Chr7:81094943-81200540 (-)
C3H/HeJ	MGP_C3HHeJ_G0032132	protein coding gene	Chr7:83849762-83959344 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032911	protein coding gene	Chr7:86670312-86779938 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029919	protein coding gene	Chr7:83919293-84016801 (-)
CAST/EiJ	MGP_CASTEiJ_G0031460	protein coding gene	Chr7:74784892-74896122 (-)
CBA/J	MGP_CBAJ_G0032098	protein coding gene	Chr7:89574004-89690708 (-)
DBA/2J	MGP_DBA2J_G0032253	protein coding gene	Chr7:79965518-80075178 (-)
FVB/NJ	MGP_FVBNJ_G0032208	protein coding gene	Chr7:79901937-80015453 (-)
LP/J	MGP_LPJ_G0032334	protein coding gene	Chr7:84636845-84749642 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032245	protein coding gene	Chr7:89639713-89755961 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032929	protein coding gene	Chr7:82643708-82755899 (-)
PWK/PhJ	MGP_PWKPhJ_G0031180	protein coding gene	Chr7:73179679-73286380 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031021	protein coding gene	Chr7:69656635-69762727 (-)
WSB/EiJ	MGP_WSBEiJ_G0031578	protein coding gene	Chr7:83009111-83118535 (-)

Human Ortholog

CPEB1, cytoplasmic polyadenylation element binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPEB1, cytoplasmic polyadenylation element binding protein 1
Synonyms

CPEB, CPEB-1, CPE-BP1, h-CPEB, hCPEB-1
Links

HGNC:21744

NCBI Gene ID: 64506

neXtProt AC: NX_Q9BZB8

UniProt: Q9BZB8
Chr Location

15q25.2; chr15:82543201-82648861 (-) GRCh38

MGI Vertebrate Homology

Cpeb1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CPEB1
Gene Tree

Cpeb1

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Cpeb1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are viable and overtly normal but display a developmental arrest of both female and male germ cells at the pachytene stage, defective synaptonemal complex formation, and impaired neuronal synaptic plasticity.

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All GO Annotations

62
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

52
cDNA Data

15
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cpeb1

ZFIN cpeb1b

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All Sequences

100
RefSeq

52
UniProt

3
CCDS

CCDS40007.1, CCDS57557.1

Ensembl

ENSMUSG00000025586 (Evidence)
NCBI Gene

12877

			Length	Strain/Species	Flank
genomic	12877	NCBI Gene Model \| MGI Sequence Detail	108434	C57BL/6J	± kb
transcript	NM_001412278	RefSeq \| MGI Sequence Detail	3237	C57BL/6
polypeptide	P70166	UniProt \| EBI \| MGI Sequence Detail	561	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005805 cytoplasmic polyadenylation element-binding protein 1

(term hierarchy)
InterPro Domains

IPR038446 CEBP, ZZ domain superfamily

IPR034977 CPEB-1, RNA recognition motif 1

IPR034819 Cytoplasmic polyadenylation element-binding protein

IPR032292 Cytoplasmic polyadenylation element-binding protein 1, N-terminal

IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

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All nucleic 17

cDNA 15

Primer pair 2

Microarray probesets 3

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MGD-MRK-37486, MGI:2142147

Summaries

All 82

Developmental Gene Expression 16

Gene Ontology 16

Phenotypes 22
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:338979 Zhang Z, et al., PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1. Development. 2023 Jun 15;150(12):dev201572

TSS for Cpeb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73335	Chr7:81105237-81105249 (-)	-36 bp
Tssr73334	Chr7:81105189-81105226 (-)	-1 bp
Tssr73333	Chr7:81105134-81105145 (-)	67 bp
Tssr73332	Chr7:81104499-81104512 (-)	701 bp
Tssr73331	Chr7:81022216-81022254 (-)	82,972 bp
Tssr73330	Chr7:81022168-81022206 (-)	83,020 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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