Mlana MGI Mouse Gene Detail - MGI:108454

Symbol

Mlana
Name

melan-A
Synonyms

A930034P04Rik, Mart1

Feature Type

protein coding gene
IDs

MGI:108454
NCBI Gene: 77836
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:29675224-29686034 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 24.28 cM, cytoband C2
Mapping Data

3 experiments

SNPs within 2kb

481 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108454	protein coding gene	Chr19:29674956-29686034 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025026	protein coding gene	Chr19:28172994-28183501 (+)
A/J	MGP_AJ_G0025003	protein coding gene	Chr19:26766322-26776945 (+)
AKR/J	MGP_AKRJ_G0024971	protein coding gene	Chr19:27712233-27723484 (+)
BALB/cJ	MGP_BALBcJ_G0025002	protein coding gene	Chr19:26801903-26812293 (+)
C3H/HeJ	MGP_C3HHeJ_G0024758	protein coding gene	Chr19:27691292-27701689 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025443	protein coding gene	Chr19:28938330-28950634 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022862	protein coding gene	Chr19:26713918-26724110 (+)
CAST/EiJ	MGP_CASTEiJ_G0024228	protein coding gene	Chr19:27527534-27538090 (+)
CBA/J	MGP_CBAJ_G0024736	protein coding gene	Chr19:30298675-30309171 (+)
DBA/2J	MGP_DBA2J_G0024868	protein coding gene	Chr19:26710908-26721675 (+)
FVB/NJ	MGP_FVBNJ_G0024830	protein coding gene	Chr19:26554719-26565110 (+)
LP/J	MGP_LPJ_G0024953	protein coding gene	Chr19:28163961-28174372 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024857	protein coding gene	Chr19:30230869-30241440 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025498	protein coding gene	Chr19:27737896-27748423 (+)
PWK/PhJ	MGP_PWKPhJ_G0023976	protein coding gene	Chr19:26375754-26386543 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023780	protein coding gene	Chr19:27017222-27029996 (+)
WSB/EiJ	MGP_WSBEiJ_G0024295	protein coding gene	Chr19:27777299-27792690 (+)

Human Ortholog

MLANA, melan-A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MLANA, melan-A
Synonyms

MART-1, MART1
Links

HGNC:7124

NCBI Gene ID: 2315

neXtProt AC: NX_Q16655

UniProt: Q16655
Chr Location

9p24.1; chr9:5890889-5910606 (+) GRCh38

MGI Vertebrate Homology

Mlana stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MLANA
Gene Tree

Mlana

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

2
Targeted

5
Genomic Mutations

3 involving Mlana
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit dilute coat color, reduced hair number, reduced melanin and eumelanin and abnormal melanosome morphology in the hair follicle.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

6
cDNA Data

11
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mlana

ZFIN mlana

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All Sequences

34
RefSeq

4
UniProt

3
CCDS

CCDS29739.1

Ensembl

ENSMUSG00000024806 (Evidence)
NCBI Gene

77836

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024806	Ensembl Gene Model \| MGI Sequence Detail	10811	C57BL/6J	± kb
transcript	ENSMUST00000025719	Ensembl \| MGI Sequence Detail	906	Not Applicable
polypeptide	ENSMUSP00000025719	Ensembl \| MGI Sequence Detail	113	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR029242 Protein melan-A

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All nucleic 12

cDNA 12

Microarray probesets 2

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MGD-MRK-37498, MGI:1925086

Summaries

All 39

Developmental Gene Expression 6

Gene Ontology 2

Phenotypes 6
Earliest

J:38811 Zhai Y, et al., Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100. J Immunother. 1997 Jan;20(1):15-25
Latest

J:344153 Raymundo JR, et al., KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions and their impairment causes aplasia cutis. J Clin Invest. 2023 Dec 19;:e174138

TSS for Mlana:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155907	Chr19:29675305-29675327 (+)	92 bp
Tssr155908	Chr19:29681192-29681206 (+)	5,975 bp
Tssr155909	Chr19:29681223-29681243 (+)	6,009 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24