Ntan1 MGI Mouse Gene Detail - MGI:108471

Symbol

Ntan1
Name

N-terminal Asn amidase
Synonyms

asparagine-specific N-terminal amidase

Feature Type

protein coding gene
IDs

MGI:108471
NCBI Gene: 18203
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:13636709-13653315 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 9.64 cM
Mapping Data

3 experiments

SNPs within 2kb

464 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108471	protein coding gene	Chr16:13636629-13653315 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022536	protein coding gene	Chr16:10818888-10848400 (+)
A/J	MGP_AJ_G0022498	protein coding gene	Chr16:10227949-10243696 (+)
AKR/J	MGP_AKRJ_G0022474	protein coding gene	Chr16:10673279-10689445 (+)
BALB/cJ	MGP_BALBcJ_G0022502	protein coding gene	Chr16:10391857-10410346 (+)
C3H/HeJ	MGP_C3HHeJ_G0022269	protein coding gene	Chr16:10766038-10782667 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022951	protein coding gene	Chr16:10982830-11000158 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020471	protein coding gene	Chr16:10317976-10333307 (+)
CAST/EiJ	MGP_CASTEiJ_G0021796	protein coding gene	Chr16:10783747-10801445 (+)
CBA/J	MGP_CBAJ_G0022238	protein coding gene	Chr16:11514878-11535369 (+)
DBA/2J	MGP_DBA2J_G0022369	protein coding gene	Chr16:10216599-10232604 (+)
FVB/NJ	MGP_FVBNJ_G0022345	protein coding gene	Chr16:10203762-10219395 (+)
LP/J	MGP_LPJ_G0022437	protein coding gene	Chr16:10727609-10743803 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022367	protein coding gene	Chr16:11138669-11157988 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022964	protein coding gene	Chr16:10648349-10665874 (+)
PWK/PhJ	MGP_PWKPhJ_G0021538	protein coding gene	Chr16:10482297-10498392 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021366	protein coding gene	Chr16:10638334-10654111 (+)
WSB/EiJ	MGP_WSBEiJ_G0021844	protein coding gene	Chr16:10664659-10689728 (+)

Human Ortholog

NTAN1, N-terminal asparagine amidase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NTAN1, N-terminal asparagine amidase
Synonyms

PNAA, PNAD
Links

HGNC:29909

NCBI Gene ID: 123803

neXtProt AC: NX_Q96AB6

UniProt: Q96AB6
Chr Location

16p13.11; chr16:15037854-15056079 (-) GRCh38

MGI Vertebrate Homology

Ntan1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NTAN1
Gene Tree

Ntan1

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

9
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available

Homozygous mutant mice exhibit behavioral and learning defects including abnormal spontaneous activity, impaired spatial memory, and reduced exploratory activity in the presence of conspecifics.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

892
Tissues

150
cDNA Data

19
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ntan1

ZFIN ntan1

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All Sequences

80
RefSeq

29
UniProt

3
CCDS

CCDS27969.1, CCDS88878.1

Ensembl

ENSMUSG00000022681 (Evidence)
NCBI Gene

18203

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022681	Ensembl Gene Model \| MGI Sequence Detail	16607	C57BL/6J	± kb
transcript	ENSMUST00000023362	Ensembl \| MGI Sequence Detail	1175	Not Applicable
polypeptide	ENSMUSP00000023362	Ensembl \| MGI Sequence Detail	310	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011458 protein N-terminal asparagine amidohydrolase

(term hierarchy)
EC

3.5.1.121
InterPro Domains

IPR026750 Protein N-terminal asparagine amidohydrolase

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All nucleic 25

Genomic 3

cDNA 20

Primer pair 2

Microarray probesets 4

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MGD-MRK-37515

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 11
Earliest

J:36619 Grigoryev S, et al., A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway. J Biol Chem. 1996 Nov 8;271(45):28521-32
Latest

J:310429 Furtado GC, et al., TNFalpha-dependent development of lymphoid tissue in the absence of RORgammat+ lymphoid tissue inducer cells. Mucosal Immunol. 2014;7(3):602-14

TSS for Ntan1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137161	Chr16:13636719-13636747 (+)	24 bp
Tssr137162	Chr16:13637170-13637233 (+)	493 bp
Tssr137163	Chr16:13646871-13646893 (+)	10,173 bp
Tssr137164	Chr16:13648430-13648441 (+)	11,727 bp
Tssr137165	Chr16:13648460-13648465 (+)	11,754 bp
Tssr137166	Chr16:13648472-13648483 (+)	11,769 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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