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Meis3 Gene Detail
Summary
  • Symbol
    Meis3
  • Name
    Meis homeobox 3
  • Synonyms
    Mrg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108519
    NCBI Gene: 17537
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15909015-15920429 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108519
 protein coding gene Chr7:15908684-15920435 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031701
 protein coding gene Chr7:13832274-13847363 (+)
A/J MGP_AJ_G0031673
 protein coding gene Chr7:13636963-13648964 (+)
AKR/J MGP_AKRJ_G0031598
 protein coding gene Chr7:13938570-13949885 (+)
BALB/cJ MGP_BALBcJ_G0031680
 protein coding gene Chr7:13734894-13746116 (+)
C3H/HeJ MGP_C3HHeJ_G0031402
 protein coding gene Chr7:14114856-14126731 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032146
 protein coding gene Chr7:14589403-14602471 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029225
 protein coding gene Chr7:15191806-15202951 (+)
CAST/EiJ MGP_CASTEiJ_G0030753
 protein coding gene Chr7:10886327-10897645 (+)
CBA/J MGP_CBAJ_G0031361
 protein coding gene Chr7:15043259-15060283 (+)
DBA/2J MGP_DBA2J_G0031517
 protein coding gene Chr7:13521018-13532242 (+)
FVB/NJ MGP_FVBNJ_G0031473
 protein coding gene Chr7:13414154-13426265 (+)
LP/J MGP_LPJ_G0031602
 protein coding gene Chr7:14107113-14119839 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031508
 protein coding gene Chr7:15015289-15029753 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032175
 protein coding gene Chr7:13715495-13727427 (+)
PWK/PhJ MGP_PWKPhJ_G0030477
 protein coding gene Chr7:11028781-11041870 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030850
 protein coding gene Chr7:13751366-13765730 (+)



Homology
more
  • Human Ortholog
    MEIS3, Meis homeobox 3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEIS3, Meis homeobox 3
  • Synonyms
    MRG2
  • Links
    NCBI Gene ID: 56917
    neXtProt AC: NX_Q99687
    UniProt: Q99687

  • Chr Location
    19q13.32; chr19:47403124-47422233 (-)  GRCh38
  • Human Ortholog
    MEIS3P1, Meis homeobox 3 pseudogene 1
  • Synonyms
    MEIS3, MEIS4, MRG2
  • Links
    NCBI Gene ID: 4213
    UniProt: A6NDR6

  • Chr Location
    17p12; chr17:15786618-15789705 (+)  GRCh38
  • Human Ortholog
    MEIS3P2, Meis homeobox 3 pseudogene 2
  • Links
    NCBI Gene ID: 257468

  • Chr Location
    17p11.2; chr17:20588850-20590815 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    910
  • Tissues
    139
  • cDNA Data
    16
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041420 Ensembl Gene Model | MGI Sequence Detail 11415 C57BL/6J ±  kb
    transcript ENSMUST00000002495 Ensembl | MGI Sequence Detail 1731 Not Applicable  
    polypeptide ENSMUSP00000002495 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 3
      cDNA 16
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37563, MGI:2141999
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 25
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:37072 Nakamura T, et al., Identification of a new family of Pbx-related homeobox genes. Oncogene. 1996 Nov 21;13(10):2235-42
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory