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Tfpi2 Gene Detail
Summary
  • Symbol
    Tfpi2
  • Name
    tissue factor pathway inhibitor 2
  • Synonyms
    PP5/TFPI-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108543
    NCBI Gene: 21789
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:3962595-3988919 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 1.81 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    833 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108543
 protein coding gene Chr6:3962589-3988977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030423
 protein coding gene Chr6:695845-722516 (-)
A/J MGP_AJ_G0030396
 protein coding gene Chr6:677737-705138 (-)
AKR/J MGP_AKRJ_G0030323
 protein coding gene Chr6:721053-746848 (-)
BALB/cJ MGP_BALBcJ_G0030405
 protein coding gene Chr6:674217-699954 (-)
C3H/HeJ MGP_C3HHeJ_G0030119
 protein coding gene Chr6:697755-723921 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030860
 protein coding gene Chr6:723877-751234 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028071
 protein coding gene Chr6:497545-522745 (-)
CAST/EiJ MGP_CASTEiJ_G0029520
 protein coding gene Chr6:682998-714027 (-)
CBA/J MGP_CBAJ_G0030097
 protein coding gene Chr6:744869-773454 (-)
DBA/2J MGP_DBA2J_G0030241
 protein coding gene Chr6:675126-702258 (-)
FVB/NJ MGP_FVBNJ_G0030195
 protein coding gene Chr6:681316-706376 (-)
LP/J MGP_LPJ_G0030328
 protein coding gene Chr6:687250-715357 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030231
 protein coding gene Chr6:800830-831225 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030890
 protein coding gene Chr6:660016-687731 (-)
PWK/PhJ MGP_PWKPhJ_G0029235
 protein coding gene Chr6:607585-635678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029071
 protein coding gene Chr6:702557-729935 (-)
WSB/EiJ MGP_WSBEiJ_G0029597
 protein coding gene Chr6:673662-699033 (-)



Homology
more
  • Human Ortholog
    TFPI2, tissue factor pathway inhibitor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFPI2, tissue factor pathway inhibitor 2
  • Synonyms
    PP5, REF1, TFPI-2
  • Links
    NCBI Gene ID: 7980
    neXtProt AC: NX_P48307
    UniProt: P48307

  • Chr Location
    7q21.3; chr7:93885396-93890753 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TFPI2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to P. aeruginosa infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    16
  • cDNA Data
    17
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029664 Ensembl Gene Model | MGI Sequence Detail 26325 C57BL/6J ±  kb
    transcript ENSMUST00000031674 Ensembl | MGI Sequence Detail 1530 Not Applicable  
    polypeptide ENSMUSP00000031674 Ensembl | MGI Sequence Detail 230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000016280 tissue factor pathway inhibitor 2
      (term hierarchy)
    • InterPro Domains
      IPR050098 Kunitz-type Serine Protease Inhibitor
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
      IPR008296 Tissue factor pathway inhibitor-like
    • GlyGen
      O35536 2 sites
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37587, MGI:2141606
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:37031 Miyagi Y, et al., Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. DNA Cell Biol. 1996 Nov;15(11):947-54
    • Latest
      J:353457 Gu T, et al., Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer. Cancer Lett. 2024 Sep 28;600:217182
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory