Tsc22d1 MGI Mouse Gene Detail - MGI:109127 - TSC22 domain family, member 1

Symbol

Tsc22d1
Name

TSC22 domain family, member 1
Synonyms

Egr5, Tgfb1i4, TSC-22

Feature Type

protein coding gene
IDs

MGI:109127
NCBI Gene: 21807
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr14:76652401-76745205 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 40.44 cM
Mapping Data

4 experiments

SNPs within 2kb

2693 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109127	protein coding gene	Chr14:76652401-76745205 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021580	protein coding gene	Chr14:71346458-71444814 (+)
A/J	MGP_AJ_G0021538	protein coding gene	Chr14:69688916-69782940 (+)
AKR/J	MGP_AKRJ_G0021515	protein coding gene	Chr14:71769496-71865028 (+)
BALB/cJ	MGP_BALBcJ_G0021545	protein coding gene	Chr14:69496237-69589813 (+)
C3H/HeJ	MGP_C3HHeJ_G0021322	protein coding gene	Chr14:71485620-71581308 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021985	protein coding gene	Chr14:74443536-74544236 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019523	protein coding gene	Chr14:67287844-67380154 (+)
CAST/EiJ	MGP_CASTEiJ_G0020839	protein coding gene	Chr14:68199649-68296832 (+)
CBA/J	MGP_CBAJ_G0021290	protein coding gene	Chr14:76835489-76946157 (+)
DBA/2J	MGP_DBA2J_G0021413	protein coding gene	Chr14:69087491-69180133 (+)
FVB/NJ	MGP_FVBNJ_G0021391	protein coding gene	Chr14:68433664-68526417 (+)
LP/J	MGP_LPJ_G0021483	protein coding gene	Chr14:72472186-72567901 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021418	protein coding gene	Chr14:75529625-75629538 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022008	protein coding gene	Chr14:71044533-71143607 (+)
PWK/PhJ	MGP_PWKPhJ_G0020582	protein coding gene	Chr14:65838183-65935188 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020419	protein coding gene	Chr14:67013408-67103615 (+)
WSB/EiJ	MGP_WSBEiJ_G0020892	protein coding gene	Chr14:71396622-71493342 (+)

Human Ortholog

TSC22D1, TSC22 domain family member 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSC22D1, TSC22 domain family member 1
Synonyms

HUCEP-2, Ptg-2, TGFB1I4, TSC22
Links

HGNC:16826

NCBI Gene ID: 8848

neXtProt AC: NX_Q15714

UniProt: Q15714
Chr Location

13q14.11; chr13:44432143-44577344 (-) GRCh38

MGI Vertebrate Homology

Tsc22d1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: TSC22D1
Gene Tree

Tsc22d1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

43
Targeted

1
Genomic Mutations

1 involving Tsc22d1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

90 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mcie homozygous for a null allele exhibit increased proliferation of bone marrow cells and decreased kidney and heart weights.

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1065
Tissues

321
cDNA Data

28
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tsc22d1

ZFIN tsc22d1

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All Sequences

128
RefSeq

35
UniProt

12
CCDS

CCDS27285.2, CCDS27286.1, CCDS49545.1, CCDS79344.1, CCDS79345.1

Ensembl

ENSMUSG00000022010 (Evidence)
NCBI Gene

21807

			Length	Strain/Species	Flank
genomic	21807	NCBI Gene Model \| MGI Sequence Detail	92805	C57BL/6J	± kb
transcript	NM_001310646	RefSeq \| MGI Sequence Detail	5016	ZRU/MplStud
polypeptide	P62500	UniProt \| EBI \| MGI Sequence Detail	1077	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000016711 TSC22 domain family protein 1

(term hierarchy)
InterPro Domains

IPR000580 TSC22/Bun

IPR047862 TSC22/Bun, conserved site
GlyGen

P62500 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

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All nucleic 35

cDNA 29

Primer pair 4

Other 2

Microarray probesets 5

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MGD-MRK-36343, MGD-MRK-38171, MGI:107766, MGI:2145575, MGI:2145793

Summaries

All 70

Developmental Gene Expression 23

Gene Ontology 8

Phenotypes 10
Earliest

J:1170 Shibanuma M, et al., Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. J Biol Chem. 1992 May 25;267(15):10219-24
Latest

J:350824 Dusing M, et al., Neurovascular Development in Pten and Tsc2 Mouse Mutants. eNeuro. 2023 Feb;10(2):ENEURO.0340-22.2023

TSS for Tsc22d1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126708	Chr14:76652172-76652233 (+)	-198 bp
Tssr126709	Chr14:76652234-76652263 (+)	-152 bp
Tssr126710	Chr14:76652369-76652414 (+)	-9 bp
Tssr126711	Chr14:76652417-76652436 (+)	26 bp
Tssr126712	Chr14:76652516-76652531 (+)	123 bp
Tssr126713	Chr14:76652789-76652814 (+)	401 bp
Tssr126714	Chr14:76664753-76664761 (+)	12,356 bp
Tssr126716	Chr14:76673696-76673745 (+)	21,320 bp
Tssr126717	Chr14:76675852-76675857 (+)	23,454 bp
Tssr126718	Chr14:76680149-76680154 (+)	27,751 bp
Tssr126719	Chr14:76714328-76714345 (+)	61,936 bp
Tssr126720	Chr14:76714353-76714370 (+)	61,961 bp
Tssr126721	Chr14:76714545-76714580 (+)	62,162 bp
Tssr126722	Chr14:76716736-76716747 (+)	64,341 bp
Tssr126723	Chr14:76725159-76725188 (+)	72,773 bp
Tssr126724	Chr14:76725199-76725212 (+)	72,805 bp
Tssr126725	Chr14:76725977-76725981 (+)	73,578 bp
Tssr126726	Chr14:76741625-76741689 (+)	89,256 bp
Tssr126727	Chr14:76741946-76741961 (+)	89,553 bp
Tssr126728	Chr14:76741989-76742000 (+)	89,594 bp
Tssr126729	Chr14:76744585-76744604 (+)	92,194 bp
Tssr126730	Chr14:76744861-76744883 (+)	92,471 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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